L
Lucía Opazo
Researcher at University of Chile
Publications - 11
Citations - 241
Lucía Opazo is an academic researcher from University of Chile. The author has contributed to research in topics: Radical & Cyclic voltammetry. The author has an hindex of 4, co-authored 9 publications receiving 227 citations. Previous affiliations of Lucía Opazo include University of the Republic.
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Journal ArticleDOI
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.
Lucía Otero,Marisol Vieites,Lucía Boiani,Ana Denicola,Carolina Rigol,Lucía Opazo,Claudio Olea-Azar,Juan Diego Maya,Antonio Morello,R Luise Krauth-Siegel,Oscar E. Piro,Eduardo E. Castellano,Mercedes González,Dinorah Gambino,Hugo Cerecetto +14 more
TL;DR: Although the complexes showed strong DNA binding, all data strongly suggest that the main trypanocidal mechanism of action is the production of oxidative stress as a result of their bioreduction and extensive redox cycling.
Journal ArticleDOI
ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes.
Lucía Otero,Christian Folch,Germán Barriga,Carolina Rigol,Lucía Opazo,Marisol Vieites,Dinorah Gambino,Hugo Cerecetto,Ester Norambuena,Claudio Olea-Azar +9 more
TL;DR: The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however the authors observed great differences between 5-nitrofurane and 5-Nitrofurylacroleine derivatives.
Journal ArticleDOI
Esr and spin trapping studies of two new potential ntitrypanosomal drugs
Claudio Olea-Azar,Carolina Rigol,Lucía Opazo,Antonio Morello,Juan Diego Maya,Yolanda Repetto,Gabriela Aguirre,Hugo Cerecetto,Rossanna Di Maio,Mercedes González,Williams Porca +10 more
TL;DR: In this paper, the electron spin resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by trypanosoma cruzi reduction were analyzed.
Journal ArticleDOI
ESR and electrochemical study of 5-nitroindazole derivatives with antiprotozoal activity.
Claudio Olea-Azar,Hugo Cerecetto,Alejandra Gerpe,Mercedes González,Vicente J. Arán,Carolina Rigol,Lucía Opazo +6 more
TL;DR: The electrochemistry of 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives were characterized using cyclic voltammetry in DMSO and nitro anion radicals obtained by electrolytic reduction of these derivatives were measured and analyzed using electron spin resonance spectroscopy.
Journal ArticleDOI
ESR and electrochemical studies of 2-acylpyridines and 6,6'-diacyl-2,2'-bipyridines.
Claudio Olea-Azar,Belén Abarca,Ester Norambuena,Lucía Opazo,Carolina Rigol,Rafael Ballesteros,Mimoun Chadlaoui +6 more
TL;DR: The ESR spectra of radicals obtained by electrolytic reduction of 2-acylpyridine and 6,6'-diacyl-2,2'-bipyridines were measured in dimethylsulfoxide and analyzed by quantum chemical calculations, and the theoretical results are in complete agreement with the experimental results.