C
Claudio Olea-Azar
Researcher at University of Chile
Publications - 177
Citations - 4728
Claudio Olea-Azar is an academic researcher from University of Chile. The author has contributed to research in topics: Radical & Spin trapping. The author has an hindex of 37, co-authored 171 publications receiving 4246 citations. Previous affiliations of Claudio Olea-Azar include University of the Republic & National Institute of Radiological Sciences.
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Journal ArticleDOI
Complexation of quercetin with three kinds of cyclodextrins: an antioxidant study.
TL;DR: The stoichiometric ratios and stability constants describing the extent of formation of the complexes have been determined by phase-solubility measurements and indicated that the complexes formed maintained the quercetin antioxidant activity.
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Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.
Lucía Otero,Marisol Vieites,Lucía Boiani,Ana Denicola,Carolina Rigol,Lucía Opazo,Claudio Olea-Azar,Juan Diego Maya,Antonio Morello,R Luise Krauth-Siegel,Oscar E. Piro,Eduardo E. Castellano,Mercedes González,Dinorah Gambino,Hugo Cerecetto +14 more
TL;DR: Although the complexes showed strong DNA binding, all data strongly suggest that the main trypanocidal mechanism of action is the production of oxidative stress as a result of their bioreduction and extensive redox cycling.
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1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships.
Hugo Cerecetto,R. Di Maio,Mercedes González,M. Risso,P. Saenz,Gustavo Seoane,Ana Denicola,Gonzalo Peluffo,C. Quijano,Claudio Olea-Azar +9 more
TL;DR: Electrochemical studies and ESR spectroscopy show that the highest activities observed are associated with the facile monoelectronation of the N-oxide moiety, and Lipophilic-hydrophilic balance of the compounds could also play an important role in their effectiveness as antichagasic drugs.
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Generation of superoxide radicals by copper-glutathione complexes: redox-consequences associated with their interaction with reduced glutathione.
Hernán Speisky,Maritza Gómez,Francesca Burgos-Bravo,Camilo López-Alarcón,Carolina Jullian,Claudio Olea-Azar,Margarita E. Aliaga +6 more
TL;DR: The superoxide-generating capacity of the Cu(I)-[GSH](2) complex is investigated, the occurrence and chemical nature of the oxidized complex which is formed upon removing of superoxide radicals from the former reaction are demonstrated, and some of the redox consequences associated with the interaction are addressed.
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In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones.
Gabriela Aguirre,Lucía Boiani,Hugo Cerecetto,Marcelo Fernández,Mercedes González,Ana Denicola,Lucía Otero,Dinorah Gambino,Carolina Rigol,Claudio Olea-Azar,Mario Faundez +10 more
TL;DR: The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, is described and these compounds are among the most potent 5-nitrofuryl derivatives tested against this parasite.