H
Hugo Cerecetto
Researcher at University of the Republic
Publications - 269
Citations - 7085
Hugo Cerecetto is an academic researcher from University of the Republic. The author has contributed to research in topics: Trypanosoma cruzi & Nifurtimox. The author has an hindex of 42, co-authored 253 publications receiving 6355 citations. Previous affiliations of Hugo Cerecetto include University of Pittsburgh.
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Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships.
Mauricio Cabrera,Macarena Simoens,Gabriela Falchi,M. Laura Lavaggi,Oscar E. Piro,Eduardo E. Castellano,Anabel Vidal,Amaia Azqueta,Antonio Monge,Adela López de Cerain,Gabriel Sagrera,Gustavo Seoane,Hugo Cerecetto,Mercedes González +13 more
TL;DR: A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenOCarcinomas cells HT-29.
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Pharmacological properties of indazole derivatives: recent developments.
TL;DR: In this presentation, recent developments in the chemistry and medicinal chemistry of indazole and its N-oxide derivatives will be reviewed.
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Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.
Lucía Otero,Marisol Vieites,Lucía Boiani,Ana Denicola,Carolina Rigol,Lucía Opazo,Claudio Olea-Azar,Juan Diego Maya,Antonio Morello,R Luise Krauth-Siegel,Oscar E. Piro,Eduardo E. Castellano,Mercedes González,Dinorah Gambino,Hugo Cerecetto +14 more
TL;DR: Although the complexes showed strong DNA binding, all data strongly suggest that the main trypanocidal mechanism of action is the production of oxidative stress as a result of their bioreduction and extensive redox cycling.
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Pharmacological Properties of Furoxans and Benzofuroxans: Recent Developments
Hugo Cerecetto,Williams Porcal +1 more
TL;DR: New anti-ulcer drugs, calcium channel modulators and vasodilator derivatives were described and they are currently in study.
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1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships.
Hugo Cerecetto,R. Di Maio,Mercedes González,M. Risso,P. Saenz,Gustavo Seoane,Ana Denicola,Gonzalo Peluffo,C. Quijano,Claudio Olea-Azar +9 more
TL;DR: Electrochemical studies and ESR spectroscopy show that the highest activities observed are associated with the facile monoelectronation of the N-oxide moiety, and Lipophilic-hydrophilic balance of the compounds could also play an important role in their effectiveness as antichagasic drugs.