L
Lucie Poggi
Researcher at University of Paris
Publications - 17
Citations - 138
Lucie Poggi is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 12 publications receiving 68 citations. Previous affiliations of Lucie Poggi include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Alternative DNA Structures In Vivo: Molecular Evidence and Remaining Questions.
TL;DR: In this article, the authors discuss and highlight evidence supporting the formation of alternative DNA structures in vivo and emphasize the role of the mismatch repair machinery in binding mispaired DNA duplexes, triggering genetic instability.
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Trinucleotide repeat instability during double-strand break repair: from mechanisms to gene therapy.
TL;DR: Different therapeutic approaches using highly specific single- or double-strand endonucleases targeted to trinucleotide repeat loci are compared, and relative efficacies and specificities of these nucleases will be discussed.
Journal ArticleDOI
TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats
Valentine Mosbach,Valentine Mosbach,Valentine Mosbach,Lucie Poggi,Lucie Poggi,Lucie Poggi,David Viterbo,David Viterbo,Marine Charpentier,Guy-Franck Richard,Guy-Franck Richard +10 more
TL;DR: It is shown that RAD51, POL32, and DNL4 are dispensable for double-strand break repair within CTG repeats, and the only required genes being RAD50, SAE2, and RAD52.
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A fast, sensitive and cost-effective method for nucleic acid detection using non-radioactive probes.
David Viterbo,David Viterbo,Astrid Marchal,Astrid Marchal,Valentine Mosbach,Valentine Mosbach,Lucie Poggi,Wilhelm Vaysse-Zinkhöfer,Wilhelm Vaysse-Zinkhöfer,Guy-Franck Richard,Guy-Franck Richard +10 more
TL;DR: A new method, based on commonly used laboratory solutions, for nucleic acid hybridization and detection with digoxigenin-labeled DNA probes is described, which is faster, more sensitive and much cheaper than a standard protocol using commercial solutions.
Journal ArticleDOI
Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions
Valentine Mosbach,David Viterbo,Stéphane Descorps-Declère,Lucie Poggi,Lucie Poggi,Wilhelm Vaysse-Zinkhöfer,Wilhelm Vaysse-Zinkhöfer,Guy-Franck Richard +7 more
TL;DR: Data show that SpCas9 may not be the best choice when inducing a double-strand break at or near a microsatellite, especially in mammalian genomes that contain many more dispersed repeated elements than the yeast genome.