L
Luis E. Perez
Researcher at University of Texas Health Science Center at San Antonio
Publications - 8
Citations - 487
Luis E. Perez is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Leishmania donovani & Visceral leishmaniasis. The author has an hindex of 6, co-authored 8 publications receiving 459 citations. Previous affiliations of Luis E. Perez include University of Texas at San Antonio & Veterans Health Administration.
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Journal ArticleDOI
Leishmania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis.
TL;DR: It is demonstrated here that although the LACK DNA vaccine induced a robust parasite-specific Th1 immune response and primed for an in vivo T-cell response to inoculated parasites, it did not induce protection against cutaneous or systemic L. major infection.
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Malnutrition Alters the Innate Immune Response and Increases Early Visceralization following Leishmania donovani Infection
TL;DR: Malnutrition causes a failure of lymph node barrier function after L. donovani infection, which may be related to excessive production of PGE2and decreased levels of IL-10 and nitric oxide.
Journal ArticleDOI
Immunogenicity of a multicomponent DNA vaccine against visceral leishmaniasis in dogs
Omar A. Saldarriaga,Bruno L. Travi,Won Park,Won Park,Luis E. Perez,Peter C. Melby,Peter C. Melby +6 more
TL;DR: The multicomponent DNA vaccine was effective in priming dogs for a parasite-specific type 1 cellular immune response, which was able to restrict parasite growth.
Journal ArticleDOI
Reduced Nitric Oxide Synthase 2 (NOS2) Promoter Activity in the Syrian Hamster Renders the Animal Functionally Deficient in NOS2 Activity and Unable to Control an Intracellular Pathogen
Luis E. Perez,Bysani Chandrasekar,Bysani Chandrasekar,Omar A. Saldarriaga,Weiguo Zhao,Weiguo Zhao,Lourdes Arteaga,Lourdes Arteaga,Bruno L. Travi,Peter C. Melby,Peter C. Melby +10 more
TL;DR: Reduced basal and IFN-γ-induced activity of the hamster NOS2 transcriptional unit accompanies the inability of the animal to control an intracellular pathogen.
Journal ArticleDOI
Leishmania amazonensis infections in Oryzomys acritus and Oryzomys nitidus from Bolivia.
Sara F. Kerr,Louise H. Emmons,Peter C. Melby,Chang Liu,Luis E. Perez,Maria D. Villegas,Robert Miranda +6 more
TL;DR: These results identify two additional species of Oryzomys as hosts of L. (L.) amazonensis, and identify an ecological region of Bolivia where L.(L.) is enzootic.