L
Luisa Borrello
Researcher at University of Catania
Publications - 7
Citations - 149
Luisa Borrello is an academic researcher from University of Catania. The author has contributed to research in topics: Nitrone & Cycloaddition. The author has an hindex of 5, co-authored 7 publications receiving 142 citations. Previous affiliations of Luisa Borrello include University of Rome Tor Vergata.
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Journal ArticleDOI
Phosphonated carbocyclic 2'-oxa-3'-azanucleosides as new antiretroviral agents.
Ugo Chiacchio,Antonio Rescifina,Daniela Iannazzo,A. Piperno,Roberto Romeo,Luisa Borrello,Maria Teresa Sciortino,Emanuela Balestrieri,Beatrice Macchi,and Antonio Mastino,Giovanni Romeo +10 more
TL;DR: Data indicate that phosphonated carbocyclic 2'-oxa-3'-azanucleosides possess the necessary requirements to efficiently counteract infections caused by human retroviruses.
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Stereoselective Synthesis and Biological Evaluations of Novel 3 '-Deoxy-4 '-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication
Ugo Chiacchio,Luisa Borrello,Lia Crispino,Antonio Rescifina,Pedro Merino,Beatrice Macchi,Emanuela Balestrieri,Antonio Mastino,A. Piperno,Giovanni Romeo +9 more
TL;DR: It is demonstrated that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be considered for novel combination therapy against HCV infection using nucleoside inhibitors and non-nucleoside inhibitor of HCV NS5B.
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Synthesis of functionalized polyhedral oligomeric silsesquioxane (POSS) macromers by microwave assisted 1,3-dipolar cycloaddition
Maria A. Chiacchio,Luisa Borrello,Giovanna Di Pasquale,Antonino Pollicino,Francesco A. Bottino,Antonio Rescifina +5 more
TL;DR: In this article, the first synthesis of isoxazolidine and isoxoxoline-POSS macromers by 1,3-dipolar cycloaddition reactions of vinyl- and styryl-pOSS with N-methyl-C-ethoxycarbonylnitrone and ethoxy carbonyl nitrile oxide, promoted by microwave irradiation was reported.
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Enantioselective synthesis of N, O-psiconucleosides
Ugo Chiacchio,Luisa Borrello,Daniela Iannazzo,Pedro Merino,Anna Piperno,Antonio Rescifina,Barbara Richichi,Giovanni Romeo +7 more
TL;DR: The first enantioselective synthesis of β- d and β- l N, O -psiconucleosides is reported in this article, which is based on the asymmetric 1,3-dipolar cycloaddition of the C -[(4 S )-2,2-dimethyl-1, 3-dioxolan-4-yl]- N -methyl nitrone with ethyl 2-acetyloxyacrylate.
Journal ArticleDOI
Phosphoroamidate derivatives of N,O-nucleosides as inhibitors of reverse transcriptase
TL;DR: In this paper, the synthesis of phosphoroamidate derivatives of adenine and 5-fluorouracil N,O-nucleoside analogues has been studied as potential antiviral prodrugs.