L
Luyan Song
Researcher at Vanderbilt University Medical Center
Publications - 7
Citations - 1040
Luyan Song is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Cotransporter & Agenesis of the corpus callosum. The author has an hindex of 7, co-authored 7 publications receiving 1009 citations.
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Journal ArticleDOI
Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.
David B. Mount,Adriana Mercado,Luyan Song,Jason Z. Xu,Alfred L. George,Eric Delpire,Gerardo Gamba +6 more
TL;DR: The expression of mouse KCC3 in Xenopus laevis oocytes reveals the expected functional characteristics of a K+Cl− cotransporter: Cl−-dependent uptake of86Rb+ which is strongly activated by cell swelling and weakly sensitive to furosemide.
Journal ArticleDOI
The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum.
Heidi Carmen Howard,David B. Mount,David B. Mount,Daniel Rochefort,Nellie Byun,Nicolas Dupré,Jianming Lu,Xuemo Fan,Luyan Song,Jean Baptiste Rivière,Claude Prévost,Jürgen Horst,Alessandro Simonati,Beate Lemcke,Richard Welch,Roger England,Frank Q. Zhan,Adriana Mercado,Adriana Mercado,William B. Siesser,Alfred L. George,Michael P. McDonald,Jean-Pierre Bouchard,Jean Mathieu,Eric Delpire,Guy A. Rouleau +25 more
TL;DR: These findings identify mutations in SLC12A6 as the genetic lesion underlying ACCPN and suggest a critical role for SLC 12A6 in the development and maintenance of the nervous system.
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Functional Comparison of the K+-Cl−Cotransporters KCC1 and KCC4
TL;DR: The functional comparison of these cloned K+-Cl− cotransporters reveals important functional, pharmacological, and kinetic differences with both physiological and mechanistic implications.
Journal ArticleDOI
Molecular, functional, and genomic characterization of human KCC2, the neuronal K–Cl cotransporter☆
Luyan Song,Adriana Mercado,Norma Vázquez,Qizhi Xie,Reshma R. Desai,Alfred L. George,Gerardo Gamba,David B. Mount +7 more
TL;DR: Initial and steady state kinetics of hKCC2-injected oocytes were performed in both isotonic and hypotonic conditions, revealing K(m)s for K(+) and Cl(-) of 9.3+/-1.8 mM and 6.8+/-0.9 mM, respectively; both affinities are significantly higher than KCC1 and KCC4.
Journal ArticleDOI
Erratum: The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum (Nature Genetics (2002) 32(384-392))
Heidi Carmen Howard,David B. Mount,Daniel Rochefort,Nellie Byun,Nicolas Dupré,Jianming Lu,X. Fan,Luyan Song,Jean-Baptiste Rivière,Claude Prévost,Jürgen Horst,Alessandro Simonati,B. Lemcke,Richard Welch,Roger England,F. Q. Zhan,Adriana Mercado,W. B. Siesser,Alfred L. George,Michael P. McDonald,Jean-Pierre Bouchard,Jean Mathieu,Eric Delpire,Guy A. Rouleau +23 more