Lv-yun Zhu

TL;DR: The current understanding of teleost immune-relevant genes for both innate and adaptive immunity, including pattern recognition receptors, antimicrobial peptides, complement molecules, lectins, interferons and signaling factors, inflammatory cytokines, chemokines, adaptive immunity relevant cytokines and negative regulators are discussed.

TL;DR: The results reveal the molecular and genetic basis of fish adaptation and response to hypoxia and air exposure, and reveal new aspects of neuro-endocrine-immune/metabolism regulatory networks that may help the fish to avoid cerebral inflammatory injury and maintain energy balance under Hypoxia.

TL;DR: Zebrafish B cells clearly showed a potent Ag-presenting ability to both soluble Ags and bacterial particles to prime naive CD4+ T cell activation, demonstrating the innate-like nature of teleost B cells in the interface of innate and adaptive immunity, and suggesting the costimulatory mechanism originated as early as the origin of adaptive immunity.

TL;DR: A novel platform that detects miRNAs at low cost and high efficacy and is the first to use CRISPR-Cas9 in miRNA detection, which is a promising approach capable of being applied in screening, diagnosing, and prognosticating of multiple diseases.

TL;DR: This is the first report showing that a possible Th2-mediated regulatory mechanism may have appeared before the divergence of teleosts and mammals, and adds greater insight into the evolutionary history of adaptive immunity.