L
Lyle Isaacs
Researcher at University of Maryland, College Park
Publications - 230
Citations - 16365
Lyle Isaacs is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Glycoluril & Cucurbituril. The author has an hindex of 62, co-authored 221 publications receiving 14781 citations. Previous affiliations of Lyle Isaacs include University of Massachusetts Amherst & ETH Zurich.
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The cucurbit[n]uril family
TL;DR: In 1981, the macrocyclic methylene-bridged glycoluril hexamer (CB[6]) was dubbed "cucurbituril" by Mock and co-workers because of its resemblance to the most prominent member of the cucurbitaceae family of plants--the pumpkin.
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The Cucurbit[n]uril Family: Prime Components for Self-Sorting Systems
Simin Liu,Christian Ruspic,Pritam Mukhopadhyay,Sriparna Chakrabarti,Peter Y. Zavalij,Lyle Isaacs +5 more
TL;DR: The values of Ka are determined for a wide range of host-guest complexes of cucurbit[n]uril (CB[n]), where n = 6-8, using 1H NMR competition experiments referenced to absolute binding constants measured by UV/vis titration.
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A strategy for the generation of surfaces presenting ligands for studies of binding based on an active ester as a common reactive intermediate: a surface plasmon resonance study.
TL;DR: Ten proteins and two low-molecular-weight ligands were immobilized on mixed self-assembled monolayers (SAMs) of alkanethiolates on gold generated from the tri(ethylene glycol)-terminated thiol 1 and these SAMs were resistant to nonspecific adsorption of proteins having a wide range of molecular weights and isoelectric points.
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A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy-entropy compensation.
Mikhail V. Rekharsky,Tadashi Mori,Cheng Yang,Young Ho Ko,Narayanan Selvapalam,Hyunuk Kim,David Sobransingh,Angel E. Kaifer,Simin Liu,Lyle Isaacs,Wei Chen,Sarvin Moghaddam,Michael K. Gilson,Kimoon Kim,Yoshihisa Inoue +14 more
TL;DR: The molecular host cucurbit[7]uril forms an extremely stable inclusion complex with the dicationic ferrocene derivative bis(trimethylammoniomethyl)ferrocene in aqueous solution that achieves its extreme affinity by overcoming the compensatory enthalpy–entropy relationship usually observed in supramolecular complexes.
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Stimuli Responsive Systems Constructed Using Cucurbit[n]uril-Type Molecular Containers
TL;DR: It is shown how the free energy associated with the formation of host–guest complexes of CB[n]-type receptors can drive conformational changes of included guests like triazene–arylene foldamers and cationic calix[4]arenes, as well as induced conformations of the hosts themselves.