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Christine P. Hans
Researcher at University of Nebraska Medical Center
Publications - 17
Citations - 5736
Christine P. Hans is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Germinal center. The author has an hindex of 12, co-authored 17 publications receiving 5249 citations.
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Journal ArticleDOI
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
Christine P. Hans,Dennis D. Weisenburger,Timothy C. Greiner,Randy D. Gascoyne,Jan Delabie,German Ott,H. Konrad Muller-Hermelink,Elias Campo,Rita M. Braziel,Elaine S. Jaffe,Zenggang Pan,Pedro Farinha,Lynette M. Smith,Brunangelo Falini,Alison H. Banham,Andreas Rosenwald,Louis M. Staudt,Joseph M. Connors,James O. Armitage,Wing C. Chan +19 more
TL;DR: In summary, immunostains can be used to determine the GCB and non-GCB subtypes of DLBCL and predict survival similar to the cDNA microarray.
Journal ArticleDOI
A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy
William W.L. Choi,Dennis D. Weisenburger,Timothy C. Greiner,Miguel A. Piris,Alison H. Banham,Jan Delabie,Rita M. Braziel,Huimin Geng,Javeed Iqbal,Georg Lenz,Julie M. Vose,Christine P. Hans,Kai Fu,Lynette M. Smith,Min Li,Zhongfeng Liu,Randy D. Gascoyne,Andreas Rosenwald,German Ott,German Ott,Lisa M. Rimsza,Elias Campo,Elaine S. Jaffe,David L. Jaye,Louis M. Staudt,Wing C. Chan +25 more
TL;DR: A new algorithm using GCET1, CD10, BCL6, MUM1, and FOXP1 was derived that closely approximated the GEP classification with 93% concordance and will facilitate risk stratification of DLBCL patients and futureDLBCL research using archival materials.
Journal ArticleDOI
Addition of Rituximab to Standard Chemotherapy Improves the Survival of Both the Germinal Center B-Cell–Like and Non–Germinal Center B-Cell–Like Subtypes of Diffuse Large B-Cell Lymphoma
Kai Fu,Dennis D. Weisenburger,William W.L. Choi,Kyle D. Perry,Lynette M. Smith,Xinlan Shi,Christine P. Hans,Timothy C. Greiner,Philip J. Bierman,R. Gregory Bociek,James O. Armitage,Wing C. Chan,Julie M. Vose +12 more
TL;DR: It is shown that the subclassification of DLBCL on the basis of the cell of origin continues to have prognostic importance in the rituximab era and was predictive for survival in both the GCB and the non-GCB subgroups.
Journal ArticleDOI
BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma
Javeed Iqbal,Warren G. Sanger,Douglas E. Horsman,Andreas Rosenwald,Diane L. Pickering,Bhavana J. Dave,Sandeep S. Dave,Li Xiao,Kajia Cao,Quiming Zhu,Simon Sherman,Christine P. Hans,Dennis D. Weisenburger,Timothy C. Greiner,Randy D. Gascoyne,German Ott,H. Konrad Muller-Hermelink,Jan Delabie,Rita M. Braziel,Elaine S. Jaffe,Elias Campo,James C. Lynch,Joseph M. Connors,Julie M. Vose,James O. Armitage,Thomas M. Grogan,Louis M. Staudt,Wing C. Chan +27 more
TL;DR: Interestingly, the t(14;18)-negative subset is dominated by overexpression of cell cycle-associated genes, indicating that these tumors are significantly more proliferative, suggesting distinctive pathogenetic mechanisms.
Journal ArticleDOI
BCL2 Expression Is a Prognostic Marker for the Activated B-Cell–Like Type of Diffuse Large B-Cell Lymphoma
Javeed Iqbal,Vishala Neppalli,George E. Wright,Bhavana J. Dave,Douglas E. Horsman,Andreas Rosenwald,James C. Lynch,Christine P. Hans,Dennis D. Weisenburger,Timothy C. Greiner,Randy D. Gascoyne,Elias Campo,German Ott,H. Konrad Muller-Hermelink,Jan Delabie,Elaine S. Jaffe,Thomas M. Grogan,Joseph M. Connors,Julie M. Vose,James O. Armitage,Louis M. Staudt,Wing C. Chan +21 more
TL;DR: Treating all DLBCL as a single entity ignores the mechanistic differences in BCL2 upregulation and obscures the prognostic significance of BCL1 expression, which should be assessed in the context ofDLBCL subgroups in future studies.