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Timothy W. McKeithan
Researcher at City of Hope National Medical Center
Publications - 55
Citations - 3233
Timothy W. McKeithan is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: T cell & Lymphoma. The author has an hindex of 28, co-authored 55 publications receiving 2783 citations. Previous affiliations of Timothy W. McKeithan include University of Nebraska Medical Center.
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Journal ArticleDOI
Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
Javeed Iqbal,Dennis D. Weisenburger,Timothy C. Greiner,Julie M. Vose,Timothy W. McKeithan,Can Küçük,Huimin Geng,Karen E Deffenbacher,Lynette M. Smith,Karen Dybkær,Shigeo Nakamura,Masao Seto,Jan Delabie,Françoise Berger,Florence Loong,Wing Yan Au,Young Hyeh Ko,Ivy Sng,James O. Armitage,Wing C. Chan +19 more
TL;DR: A molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL-not otherwise specified cases was identified and may lead to better therapies and outcome in the future.
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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Can Küçük,Bei Jiang,Xiaozhou Hu,Wenyan Zhang,John K.C. Chan,Wenming Xiao,Nathan A. Lack,Can Alkan,John C. Williams,Kendra N. Avery,Painar Kavak,Anna Scuto,Emel Sen,Philippe Gaulard,Lou Staudt,Javeed Iqbal,Weiwei Zhang,Adam Cornish,Qiang Gong,Qun-Pei Yang,Hong Sun,Francesco d'Amore,Sirpa Leppä,Weiping Liu,Kai Fu,Laurence de Leval,Timothy W. McKeithan,Wing C. Chan +27 more
TL;DR: The findings suggest that JAK-STAT pathway inhibition may represent a therapeutic strategy in NK/T-cell lymphomas and their cell lines through next generation and/or Sanger sequencing.
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Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.
Javeed Iqbal,Timothy C. Greiner,K. Patel,Bhavana J. Dave,Lynette M. Smith,J. Ji,George E. Wright,Warren G. Sanger,Diane L. Pickering,Smrati Jain,Douglas E. Horsman,Yulei Shen,Kai Fu,Dennis D. Weisenburger,C. P. Hans,Elias Campo,Randy D. Gascoyne,Andreas Rosenwald,Elaine S. Jaffe,Jan Delabie,Lisa M. Rimsza,German Ott,Hans Konrad Müller-Hermelink,Joseph M. Connors,Julie M. Vose,Timothy W. McKeithan,Louis M. Staudt,W. C. Chan +27 more
TL;DR: The biological role of BCL6 in translocated cases where repression of known target genes is not demonstrated is intriguing and warrants further investigation.
Journal ArticleDOI
The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation
Enyu Rao,Chunsun Jiang,Ming Ji,Xin Huang,Javeed Iqbal,Georg Lenz,Georg Lenz,George E. Wright,Louis M. Staudt,Yong Zhao,Timothy W. McKeithan,W. C. Chan,Kai Fu +12 more
TL;DR: It is demonstrated that the protein phosphatase PHLPP2, an important negative regulator of the PI3K/AKT pathway, was a direct target of miR-17∼92 miRNAs, in addition to PTEN and BIM, which were down-modulated in MCL cells with overexpression of the miR+92 cluster.
Journal ArticleDOI
IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma
Chao Wang,Chao Wang,Chao Wang,Timothy W. McKeithan,Qiang Gong,Weiwei Zhang,Alyssa Bouska,Andreas Rosenwald,Randy D. Gascoyne,Xiwei Wu,Jinhui Wang,Zahid Muhammad,Bei Jiang,Bei Jiang,Joseph Rohr,Joseph Rohr,Andrew Cannon,Christian Steidl,Kai Fu,Yuping Li,Stacy Hung,Dennis D. Weisenburger,Timothy C. Greiner,Lynette M. Smith,German Ott,Eleanor G. Rogan,Louis M. Staudt,Julie M. Vose,Javeed Iqbal,Wing C. Chan +29 more
TL;DR: Target resequencing on 92 cases of PTCL and frequent mutations affecting RHOA, TET2, DNMT3A, and isocitrate dehydrogenase 2 (IDH2) revealed recurrently hypermethylated genes involved in T-cell receptor signaling and T- cell differentiation that likely contribute to lymphomagenesis in AITL.