L
Lynne Cassimeris
Researcher at Lehigh University
Publications - 89
Citations - 6785
Lynne Cassimeris is an academic researcher from Lehigh University. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 44, co-authored 88 publications receiving 6474 citations. Previous affiliations of Lynne Cassimeris include University of Pennsylvania & French Institute of Health and Medical Research.
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Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.
TL;DR: It is proposed that nocodazole acts by generating TuD subunits that then alter dynamic instability in interphase cells and in vitro with purified brain tubulin, which is similar to the effects of increasing concentrations of GDP-tubulin (TuD) subunits on microtubule assembly.
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The oncoprotein 18/stathmin family of microtubule destabilizers.
TL;DR: It is suggested that phosphorylation occurs in a localized fashion, resulting in decreased microtubule destabilizing activity near chromatin or micro Tubule polymer, and a spatial gradient of inactive Op18/stathmin associated with chromatinor microtubules could contribute significantly to mitotic spindle assembly.
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Real-time observations of microtubule dynamic instability in living cells.
TL;DR: Individual microtubule dynamics were observed in real time in primary cultures of newt lung epithelium using video-enhanced differential interference contrast microscopy and digital image processing and the population appeared differentially stable.
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Oscillatory movements of monooriented chromosomes and their position relative to the spindle pole result from the ejection properties of the aster and half-spindle.
TL;DR: The oscillations of a monooriented chromosome and its position relative to the spindle pole result from an imbalance between poleward pulling forces acting at the proximal kinetochore and an ejection force acting along the chromosome, which is generated within the aster and half-spindle.
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Mechanochemical model of microtubule structure and self-assembly kinetics.
TL;DR: The model recapitulates three-dimensional tip structures and rates of assembly and disassembly for microtubules grown under standard conditions, and it is proposed that taxol may stabilize microtubule growth by reducing flexural rigidity and partial uncapping of the tubulin-GTP cap provides a possible mechanism for microTube pause events.