L
Lyubomira Chakalova
Researcher at Babraham Institute
Publications - 22
Citations - 3918
Lyubomira Chakalova is an academic researcher from Babraham Institute. The author has contributed to research in topics: Transcription (biology) & Gene. The author has an hindex of 18, co-authored 22 publications receiving 3750 citations. Previous affiliations of Lyubomira Chakalova include Macedonian Academy of Sciences and Arts.
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Journal ArticleDOI
Active genes dynamically colocalize to shared sites of ongoing transcription.
Cameron S. Osborne,Lyubomira Chakalova,Karen E. Brown,David R. F. Carter,David R. F. Carter,Alice Horton,Emmanuel Debrand,Beatriz Goyenechea,Jennifer A. Mitchell,Susana Lopes,Susana Lopes,Wolf Reik,Peter Fraser +12 more
TL;DR: It is shown that, during transcription in vivo, distal genes colocalize to the same transcription factory at high frequencies.
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Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Stefan Schoenfelder,Tom Sexton,Lyubomira Chakalova,Nathan F. Cope,Alice Horton,Simon Andrews,Sreenivasulu Kurukuti,Jennifer A. Mitchell,David Umlauf,Daniela S. Dimitrova,Christopher H. Eskiw,Yanquan Luo,Chia-Lin Wei,Yijun Ruan,James J. Bieker,Peter Fraser +15 more
TL;DR: The first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues reveals extensive and preferential intra- and interchromosomal transcription interactomes, establishing a new gene expression paradigm.
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Long-range chromatin regulatory interactions in vivo
TL;DR: The development of a widely applicable in situ technique to tag and recover chromatin in the immediate vicinity of an actively transcribed gene and provide the first direct evidence of long-range enhancer communication is reported.
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Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.
Cameron S. Osborne,Lyubomira Chakalova,Jennifer A. Mitchell,Alice Horton,Andrew L. Wood,Daniel J. Bolland,Anne E. Corcoran,Peter Fraser +7 more
TL;DR: The results show that transcriptional activation of IE genes involves rapid relocation to preassembled transcription factories, implying a direct link between the nonrandom interchromosomal organization of transcribed genes at transcription factories and the incidence of specific chromosomal translocations.
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Antisense intergenic transcription in V(D)J recombination
Daniel J. Bolland,Andrew L. Wood,Colette Johnston,Sam F Bunting,Geoff Morgan,Lyubomira Chakalova,Peter Fraser,Anne E. Corcoran +7 more
TL;DR: It is proposed that antisense transcription remodels the V region to facilitate VH-to-DJH recombination and have wider implications for V(D)J recombination of other antigen receptor loci and developmental regulation of multigene loci.