J
James J. Bieker
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 95
Citations - 6337
James J. Bieker is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: KLF1 & Transcription factor. The author has an hindex of 32, co-authored 87 publications receiving 5955 citations.
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A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins.
I J Miller,James J. Bieker +1 more
TL;DR: The tissue expression pattern of EKLF, in conjunction with its function as a transcriptional activator, strongly suggests that the EKlF protein may be intimately involved in establishment and/or maintenance of the erythroid cell phenotype.
Journal ArticleDOI
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Stefan Schoenfelder,Tom Sexton,Lyubomira Chakalova,Nathan F. Cope,Alice Horton,Simon Andrews,Sreenivasulu Kurukuti,Jennifer A. Mitchell,David Umlauf,Daniela S. Dimitrova,Christopher H. Eskiw,Yanquan Luo,Chia-Lin Wei,Yijun Ruan,James J. Bieker,Peter Fraser +15 more
TL;DR: The first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues reveals extensive and preferential intra- and interchromosomal transcription interactomes, establishing a new gene expression paradigm.
Journal ArticleDOI
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases
Wenjun Zhang,James J. Bieker +1 more
TL;DR: The results establish EKLF as a tissue-specific transcription factor that undergoes post-translational acetylation and suggest a mechanism by which EkLF is able to alter chromatin structure and induce beta-globin expression within the beta-like globin cluster.
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A SWI/SNF–Related Chromatin Remodeling Complex, E-RC1, Is Required for Tissue-Specific Transcriptional Regulation by EKLF In Vitro
TL;DR: A member of the SWI/SNF family acts directly in transcriptional activation and may regulate subsets of genes by selectively interacting with specific DNA-binding proteins.