Beatriz Goyenechea

TL;DR: It is shown that, during transcription in vivo, distal genes colocalize to the same transcription factory at high frequencies.

TL;DR: The 7.2 kilobase (kb) Corfu δβ thalassemia mutation is the smallest known deletion encompassing a region upstream of the human δ gene that has been suggested to account for the vastly different phenotypes in hereditary persistence of fetal hemoglobin (HPFH) versus β thalasemia.

TL;DR: In erythroid cells, intergenic transcription in the human β-globin locus occurs over a region of greater than 250 kb including several genes in the nearby olfactory receptor gene cluster, which correlates high levels of non-S phaseintergenic transcription with domain-wide active histone modifications to histone H3.

TL;DR: The β-globin genes have become a classical model for studying regulation of gene expression and multiple levels of epigenetic regulation that coordinately ensure a highly specialised, tissue- and stage-specific gene transcription pattern are revealed.

TL;DR: A role for intergenic non-coding RNA transcription in the propagation of histone modifications over chromatin domains and epigenetic control of β-like globin gene transcription during development is demonstrated.