S
Sreenivasulu Kurukuti
Researcher at University of Hyderabad
Publications - 23
Citations - 2938
Sreenivasulu Kurukuti is an academic researcher from University of Hyderabad. The author has contributed to research in topics: Chromatin & CTCF. The author has an hindex of 12, co-authored 21 publications receiving 2746 citations. Previous affiliations of Sreenivasulu Kurukuti include Uppsala University & Macedonian Academy of Sciences and Arts.
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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
Zhihu Zhao,Gholamreza Tavoosidana,Mikael Sjölinder,Anita Göndör,Piero Mariano,Sha Wang,Chandrasekhar Kanduri,Magda Lezcano,Kuljeet Singh Sandhu,Umashankar Singh,Vinod Pant,Vijay K. Tiwari,Sreenivasulu Kurukuti,Rolf Ohlsson +13 more
TL;DR: It is found that the direct interaction between differentially methylated regions was linked to epigenetic regulation of transcription in trans and the patterns of interactions specific to the maternal H19 imprinting control region underwent reprogramming during in vitro maturation of embryonic stem cells.
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Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
Stefan Schoenfelder,Tom Sexton,Lyubomira Chakalova,Nathan F. Cope,Alice Horton,Simon Andrews,Sreenivasulu Kurukuti,Jennifer A. Mitchell,David Umlauf,Daniela S. Dimitrova,Christopher H. Eskiw,Yanquan Luo,Chia-Lin Wei,Yijun Ruan,James J. Bieker,Peter Fraser +15 more
TL;DR: The first genome-wide analysis of transcriptional interactions using the mouse globin genes in erythroid tissues reveals extensive and preferential intra- and interchromosomal transcription interactomes, establishing a new gene expression paradigm.
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CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
Sreenivasulu Kurukuti,Vijay K. Tiwari,Gholamreza Tavoosidana,Elena M. Pugacheva,Adele Murrell,Zhihu Zhao,Victor V. Lobanenkov,Wolf Reik,Rolf Ohlsson +8 more
TL;DR: Systematic chromosome conformation capture analysis of an imprinting cluster reveals that CTCF has a critical role in the epigenetic regulation of higher-order chromatin structure and gene silencing over considerable distances in the genome.
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Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of de Novo Methylation upon Maternal Inheritance
Vinod Pant,Sreenivasulu Kurukuti,Elena M. Pugacheva,Shaharum Shamsuddin,Piero Mariano,Rainer Renkawitz,Elena Klenova,Victor V. Lobanenkov,Rolf Ohlsson +8 more
TL;DR: It is proposed that site-specific interactions between various DNA-bound CTCF molecules may provide general focal points in the organization of looped chromatin domains involved in gene regulation.
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CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin
Les J. Burke,Ru Zhang,Marek Bartkuhn,Vijay K. Tiwari,Gholamreza Tavoosidana,Sreenivasulu Kurukuti,Christine Weth,Joerg Leers,Niels Galjart,Rolf Ohlsson,Rainer Renkawitz +10 more
TL;DR: It is shown that in contrast to other zinc‐finger proteins, CTCF indeed is bound to mitotic chromosomes, and the chromatin loop organized by the C TCF‐bound, differentially methylated region at the Igf2/H19 locus can be detected in mitosis.