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M

M. B. Vallerga

Researcher at Fundación Instituto Leloir

Publications -  7
Citations -  221

M. B. Vallerga is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: DNA replication & DNA repair. The author has an hindex of 6, co-authored 7 publications receiving 190 citations. Previous affiliations of M. B. Vallerga include National Scientific and Technical Research Council.

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Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

TL;DR: It is reported that in UV-irradiated cells lacking the Rad51 recombinase (Rad51), the DNA replication choreography is profoundly altered and the results reveal an unanticipated complexity in the regulation of DNA elongation across UV-damaged templates.
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UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

TL;DR: It is shown that forced p21 stabilization after UV strongly impairs damaged-DNA replication, which is associated with permanent deficiencies in the recruitment of DNA polymerases from the Y family involved in translesion DNA synthesis).
Journal ArticleDOI

Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks

TL;DR: It is shown that, in contrast to ICL-causing agents, UV radiation compromises cell survival independently from FANCD2, which protects UV-dependent, replication-coupled DSBs from aberrant processing by non-Homologous end joining, preventing the accumulation of micronuclei and chromatid aberrations including non-homologous Chromatid exchanges.