M
M. B. Vallerga
Researcher at Fundación Instituto Leloir
Publications - 7
Citations - 221
M. B. Vallerga is an academic researcher from Fundación Instituto Leloir. The author has contributed to research in topics: DNA replication & DNA repair. The author has an hindex of 6, co-authored 7 publications receiving 190 citations. Previous affiliations of M. B. Vallerga include National Scientific and Technical Research Council.
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Journal ArticleDOI
Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation
M. B. Vallerga,Sabrina F. Mansilla,María Belén Federico,Agustina P Bertolin,Vanesa Gottifredi +4 more
TL;DR: It is reported that in UV-irradiated cells lacking the Rad51 recombinase (Rad51), the DNA replication choreography is profoundly altered and the results reveal an unanticipated complexity in the regulation of DNA elongation across UV-damaged templates.
Journal ArticleDOI
Biological Dosimetry Intercomparison Exercise: An Evaluation of Triage and Routine Mode Results by Robust Methods
M. Di Giorgio,Joan Francesc Barquinero,M. B. Vallerga,A. Radl,M. R. Taja,Analia Isabel Seoane,J.C. De Luca,M. Stuck Oliveira,P. Valdivia,O. Garcia Lima,Ana I. Lamadrid,J.E. Gonzalez Mesa,I. Romero Aguilera,T. Mandina Cardoso,Y. C. Guerrero Carvajal,C. Arceo Maldonado,M. Espinoza,Wilner Martínez-López,L. Méndez-Acuña,M V Di Tomaso,Laurence Roy,Carita Lindholm,Horst Romm,I. Guclu,David Lloyd +24 more
TL;DR: An international intercomparison based on dicentric chromosome analysis for dose assessment performed in the framework of the IAEA Regional Latin American RLA/9/054 Project reinforces the view that collaborative networking in the case of a mass casualty event can be successful.
Journal ArticleDOI
UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability
Sabrina F. Mansilla,Gastón Soria,M. B. Vallerga,Martín Habif,Wilner Martínez-López,Carol Prives,Vanesa Gottifredi +6 more
TL;DR: It is shown that forced p21 stabilization after UV strongly impairs damaged-DNA replication, which is associated with permanent deficiencies in the recruitment of DNA polymerases from the Y family involved in translesion DNA synthesis).
Journal ArticleDOI
Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks
María Belén Federico,M. B. Vallerga,A. Radl,Natalia S. Paviolo,José Luis Bocco,Marina Di Giorgio,Gastón Soria,Vanesa Gottifredi +7 more
TL;DR: It is shown that, in contrast to ICL-causing agents, UV radiation compromises cell survival independently from FANCD2, which protects UV-dependent, replication-coupled DSBs from aberrant processing by non-Homologous end joining, preventing the accumulation of micronuclei and chromatid aberrations including non-homologous Chromatid exchanges.
Journal ArticleDOI
Interlaboratory comparison of dicentric chromosome assay using electronically transmitted images
Oriol Gasquez Garcia,M. Di Giorgio,M. B. Vallerga,A. Radl,M. R. Taja,Analia Isabel Seoane,J.C. De Luca,M. Stuck Oliveira,P. Valdivia,Ana I. Lamadrid,Jorge E. González,Ivonne Romero,T. Mandina,Gabriel E. Pantelias,Georgia I. Terzoudi,C. Guerrero-Carbajal,C. Arceo Maldonado,M. Espinoza,N. Oliveros,Wilner Martínez-López,M V Di Tomaso,L. Méndez-Acuña,Roser Puig,Laurence Roy,Joan Francesc Barquinero +24 more
TL;DR: The results obtained support the feasibility of networking using electronically transmitted images using image analysis systems and a global website able to be used for the different regional networks, like Share Points, will be desirable to facilitate worldwide communication.