G
Georgia I. Terzoudi
Researcher at National Centre of Scientific Research "Demokritos"
Publications - 74
Citations - 2077
Georgia I. Terzoudi is an academic researcher from National Centre of Scientific Research "Demokritos". The author has contributed to research in topics: Premature chromosome condensation & DNA repair. The author has an hindex of 24, co-authored 68 publications receiving 1786 citations.
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Journal ArticleDOI
Mechanisms of DNA double strand break repair and chromosome aberration formation.
George Iliakis,Huichen Wang,Ange Ronel Perrault,W Boecker,Bustanur Rosidi,Frank Windhofer,W Wu,J Guan,Georgia I. Terzoudi,Gabriel E. Pantelias +9 more
TL;DR: It is proposed that high speed D-NHEJ is an evolutionary development in higher eukaryotes orchestrated around the newly evolved DNA-PKcs and pre-existing factors and achieves within a few minutes restoration of chromosome integrity through an optimized synapsis mechanism operating by a sequence of protein-protein interactions in the context of chromatin and the nuclear matrix.
Journal ArticleDOI
Increased G2 chromosomal radiosensitivity in cancer patients: the role of cdk1/cyclin-B activity level in the mechanisms involved.
Georgia I. Terzoudi,T. Jung,J. Hain,J. Vrouvas,K. Margaritis,C. Donta-Bakoyianni,V. Makropoulos,Ph. Angelakis,Gabriel E. Pantelias +8 more
TL;DR: The cdk1/cyclin-B activity levels during the G2 to M transition impair DNA repair processes and play a major role in the yield of chromatid breaks induced after G2-irradiation.
Journal ArticleDOI
Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET).
Zacharenia Nikitaki,Vladimir Nikolov,Ifigeneia V. Mavragani,Emil Mladenov,Anastasios Mangelis,Danae A. Laskaratou,Georgios I Fragkoulis,Christine E. Hellweg,Olga A. Martin,Dimitris Emfietzoglou,Vasiliki I. Hatzi,Georgia I. Terzoudi,George Iliakis,Alexandros G. Georgakilas +13 more
TL;DR: Foci colocalization approaches were applied as the most current methodologies for the in situ detection of clustered DNA lesions in a variety of human normal and cancerous cell lines of varying repair efficiency and radiation qualities of increasing LET were measured.
Journal ArticleDOI
RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA).
Ursula Oestreicher,Daniel Samaga,Elizabeth A. Ainsbury,Ana Antunes,Ans Baeyens,Leonardo Barrios,Christina Beinke,P. Beukes,William F. Blakely,Alexandra Cucu,Andrea De Amicis,Julie Depuydt,Stefania De Sanctis,Marina Di Giorgio,Katalin Dobos,Inmaculada Domínguez,Pham Ngoc Duy,Marco E. Espinoza,Farrah Flegal,Markus Figel,Omar García,Octávia Monteiro Gil,Eric Gregoire,C. Guerrero-Carbajal,I. Guclu,Valeria Hadjidekova,M. Prakash Hande,Ulrike Kulka,Jennifer A. Lemon,Carita Lindholm,Florigio Lista,Katalin Lumniczky,Wilner Martínez-López,Nataliya A. Maznyk,Roberta Meschini,Radia M’kacher,Alegría Montoro,Jayne Moquet,Mercedes Moreno,Mihaela Noditi,J. Pajic,Analía Radl,Michelle Ricoul,Horst Romm,Laurence Roy,Laure Sabatier,Natividad Sebastià,Jacobus Slabbert,Sylwester Sommer,Monica Stuck Oliveira,Uma Subramanian,Yumiko Suto,Tran Que,Antonella Testa,Georgia I. Terzoudi,Anne Vral,Ruth C. Wilkins,LusiYanti Yanti,D. Zafiropoulos,Andrzej Wojcik +59 more
TL;DR: In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA.
Journal ArticleDOI
Checkpoint Abrogation in G2 Compromises Repair of Chromosomal Breaks in Ataxia Telangiectasia Cells
TL;DR: Observations represent the first direct evidence that the G(2) checkpoint facilitates repair of chromosome damage, presumably by supporting repair of DNA DSBs.