M
M.-C. Fournie-Zaluski
Researcher at French Institute of Health and Medical Research
Publications - 42
Citations - 1439
M.-C. Fournie-Zaluski is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Enkephalin & RB-101. The author has an hindex of 21, co-authored 42 publications receiving 1428 citations.
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Journal ArticleDOI
Radioimmunoassay of methionine- and leucine-enkephalins in regions of rat brain and comparison with endorphins estimated by a radioreceptor assay.
C. Gros,Philippe Pradelles,C. Rouget,O. Bepoldin,Fernand Dray,M.-C. Fournie-Zaluski,Bernard-Pierre Roques,Hélène Pollard,Catherine Llorens-Cortes,J.-C. Schwartz +9 more
TL;DR: Radioimmunoassays selective for methionine‐enkephalin (Met‐ENK) and leucineenkephalins (Leu‐ ENK) have been developed using competition towards binding of 10 pM 125I‐en kephalins to antibodies raised in rabbits against ENKs coupled to ovalbumin with carbodiimide.
Journal Article
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
Florence Noble,J M Soleilhac,Evelyne Soroca-Lucas,Serge Turcaud,M.-C. Fournie-Zaluski,Bernard-Pierre Roques +5 more
TL;DR: The preferential involvement of mu opioid receptors in the analgesic effects of endogenous enkephalins, whose extracellular levels are increased by the two RB101-generated inhibitors, is suggested.
Journal ArticleDOI
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Gilles Patey,S. de la Baume,J.-C. Schwartz,C. Gros,Bernard P. Roques,M.-C. Fournie-Zaluski,E Soroca-Lucas +6 more
TL;DR: The data indicate that enkephalinase is critically involved in the inactivation of the endogenous opioid peptide released from striatal neurons.
Journal Article
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.
Sylvie Bourgoin,D. Le Bars,F. Artaud,A.M. Clot,R Bouboutou,M.-C. Fournie-Zaluski,Bernard-Pierre Roques,M. Hamon,F. Cesselin +8 more
TL;DR: Compared to thiorphan plus bestatin, kelatorphan exerts additional inhibitory effects on dipeptidylaminopeptidase activity and the present results could indicate that this enzyme also may be involved in the inactivation of extracellular Met-enkephalin at the spinal level in rats.
Journal Article
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
TL;DR: An opposing physiological role of endogenous CCK, acting on CCK B receptors, and opioid peptides in the control of pain perception at both spinal and supraspinal levels is demonstrated.