M
M. Carmen Fernández
Researcher at University of Málaga
Publications - 34
Citations - 3056
M. Carmen Fernández is an academic researcher from University of Málaga. The author has contributed to research in topics: Bicuspid aortic valve & Aorta. The author has an hindex of 18, co-authored 33 publications receiving 2737 citations. Previous affiliations of M. Carmen Fernández include Services Hospital.
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Journal ArticleDOI
Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period
Raúl J. Andrade,M. Isabel Lucena,M. Carmen Fernández,G. Pelaez,Ketevan Pachkoria,Elena García-Ruiz,B. García-Muñoz,Rocío González-Grande,Angeles Pizarro,José Antonio Durán,Manuel Jimenez,Luis Rodrigo,Manuel Romero-Gómez,J.M. Navarro,Ramon Planas,Joan Costa,Africa Borras,Aina Soler,Javier Salmerón,Rafael Martín-Vivaldi +19 more
TL;DR: Patients with drug-induced hepatocellular jaundice have 11.7% chance of progressing to death or transplantation, and amoxicillin-clavulanate stands out as the most common drug related to DILI.
Journal ArticleDOI
Outcome of acute idiosyncratic drug‐induced liver injury: Long‐term follow‐up in a hepatotoxicity registry
Raúl J. Andrade,M. Isabel Lucena,Neil Kaplowitz,Beatriz García‐Muņoz,Y. Borraz,Ketevan Pachkoria,Miren García-Cortés,M. Carmen Fernández,G. Pelaez,Luis Rodrigo,José Antonio Durán,Joan Costa,Ramon Planas,A.M. Barriocanal,Carlos Guarner,Manuel Romero-Gómez,Teresa Muņoz‐Yagüe,Javier Salmerón,Ramón Hidalgo +18 more
TL;DR: Patients with cholestatic/mixed injury were more prone to chronicity than patients with hepatocellular injury, and cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage.
Journal ArticleDOI
Phenotypic characterization of idiosyncratic drug‐induced liver injury: The influence of age and sex
M. Isabel Lucena,Raúl J. Andrade,Neil Kaplowitz,Miren García-Cortés,M. Carmen Fernández,Manuel Romero-Gómez,Miguel Bruguera,H. Hallal,Mercedes Robles-Díaz,Jose F. Rodriguez‐González,J.M. Navarro,Javier Salmerón,Pedro Martinez‐Odriozola,Ramón Pérez-Álvarez,Y. Borraz,Ramón Hidalgo +15 more
TL;DR: Neither older age nor female sex are predisposing factors to overall DILI, however, older age is a determinant for cholestatic damage with a male predominance, whereas younger age is associated with cytolytic damage and a female overrepresentation.
Journal ArticleDOI
Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury.
Mercedes Robles Diaz,M. Isabel Lucena,Neil Kaplowitz,Camilla Stephens,Inmaculada Medina–Cáliz,Andres Gonzalez Jimenez,Eugenia Ulzurrun,Ana González,M. Carmen Fernández,Manuel Romero Gomez,Miguel Jimenez–Perez,Miguel Bruguera,Martín Prieto,Fernando Bessone,Nelia Hernández,Marco Arrese,Raúl J. Andrade +16 more
TL;DR: When applied at DILI recognition, the nR criteria for Hy's Law provides the best balance of sensitivity and specificity whereas the new composite algorithm provides additional specificity in predicting the ultimate development of ALF.
Journal ArticleDOI
Bicuspid Aortic Valves With Different Spatial Orientations of the Leaflets Are Distinct Etiological Entities
Borja Fernández,Ana C. Durán,T. Fernández-Gallego,M. Carmen Fernández,Miguel Such,J.M. Arqué,Valentín Sans-Coma +6 more
TL;DR: The R-N and R-L BAVs are different etiological entities and are the product of a morphogenetic defect that happens before the OT septation and that probably relies on an exacerbated nitric oxide-dependent epithelial-to-mesenchymal transformation.