M
M. Grieco
Researcher at University of Naples Federico II
Publications - Â 44
Citations - Â 4819
M. Grieco is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Thyroid carcinoma & Thyroid. The author has an hindex of 27, co-authored 44 publications receiving 4720 citations. Previous affiliations of M. Grieco include Mediterranea University of Reggio Calabria.
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Journal ArticleDOI
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.
M. Grieco,Massimo Santoro,Maria Teresa Berlingieri,Rosa Marina Melillo,R. Donghi,Italia Bongarzone,Marco A. Pierotti,Giuseppe Della Ports,Alfredo Fusco,Giancarlo Vecchiot +9 more
TL;DR: A novel activated oncogene resulted from the rearrangement of an unknown amino-terminal sequence to the tyrosine kinase domain of the ret proto-oncogene and was detected by transfection analysis in five out of 20 primary human thyroid papillary carcinomas and in the available lymph node metastases.
Journal ArticleDOI
Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
Massimo Santoro,Francesca Carlomagno,A Romano,Donald P. Bottaro,Nina A. Dathan,M. Grieco,Alfredo Fusco,Giancarlo Vecchio,B Matoskova,Matthias H. Kraus +9 more
TL;DR: Oncogenic conversion of RET in these neoplastic syndromes establishes germline transmission of dominant transforming genes in human cancer.
Journal ArticleDOI
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases
Alfredo Fusco,M. Grieco,M Santoro,Maria Teresa Berlingieri,Silvana Pilotti,Marco A. Pierotti,G. Della Porta,Giancarlo Vecchio +7 more
TL;DR: The detection of transforming activity in DNAs extracted from five thyroid papillary carcinomas and two of their respective lymph-nodal metastases is reported.
Journal Article
Molecular characterization of RET/PTC3; A novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma
Massimo Santoro,Nina A. Dathan,Maria Teresa Berlingieri,Italia Bongarzone,Christian Paulin,M. Grieco,Marco A. Pierotti,Giancarlo Vecchio,Alfredo Fusco +8 more
TL;DR: The identification and cloning of a novel rearranged version of the RET oncogene in a human thyroid papillary carcinoma and evidence indicating that the rearrangement leading to the generation of RET/PTC3 occurred in vivo in the original tumor DNA is provided.
Journal Article
High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma.
Italia Bongarzone,M. A. Pierotti,N Monzini,Piera Mondellini,Giacomo Manenti,R. Donghi,Silvana Pilotti,M. Grieco,M Santoro,Alfredo Fusco +9 more
TL;DR: Since both PTC, a novel rearranged form of RET, and TRK display a tyrosine protein kinase activity, it is proposed that the activation of this class of oncogenes is specifically involved in the pathogenesis of papillary thyroid cancer.