M. A. Pierotti

TL;DR: A gene classifier that can predict clinical outcome in tamoxifen-treated ER+ BC patients is developed and other genes and pathways that may elucidate further mechanisms that influence clinical outcome and prediction of response to tamoxIFen are proposed.

TL;DR: Since both PTC, a novel rearranged form of RET, and TRK display a tyrosine protein kinase activity, it is proposed that the activation of this class of oncogenes is specifically involved in the pathogenesis of papillary thyroid cancer.

TL;DR: Over‐expression of p 185 was found to be related to tumor size and grade and to LPI but not to pathologic nodal status, and showed the same correlation with a poor prognosis as in node‐positive patients.

TL;DR: Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p 53 immunostaining in a third one indicates that changes may take place early in the process of lung carcinogenesis.

TL;DR: The isolation and characterization of one of the thyroid TRK oncogenes, designated TRK-T1 is described, which is created by an intrachromosomal rearrangement that juxtaposes the 5' end of the TPR gene to the TRK tyrosine kinase domain.