M. Hillgärtner

TL;DR: In this paper, the feasibility of microcapsules based on hydrogels for transplantation of non-autologous cells and tissue fragments was shown, and the first successful long-term clinical applications were reported.

TL;DR: Encapsulation of rat islets, human monoclonal antibodies secreting hybridoma cells and murine mesenchymal stem cells transfected with cDNA encoding for bone morphogenetic protein revealed that injection of BaCl(2) crystals has no adverse side effects on cell viability and function, however, the release of low-molecular weight factors may be delayed when using alginate concentrations in the usual range.

TL;DR: Ba2+‐alginate capsules were developed that meet the requirements for long‐term immunoisolated transplantation of (allogeneic and xenogeneic) cells and tissue fragments and demonstrated that these capsules were functional over a period of more than two years.

TL;DR: HSA-stabilized microcapsules made from UHV(Lam)Alginate are apparently a promising system for immunoisolation of cells, particularly when alginate is cross-linked by injection of BaCl(2) crystals into the alginates droplets.

TL;DR: Advanced 1H NMR imaging, along with paramagnetic Cu2+ as contrast agent, can be used to validate the cross-linking process of alginates cross-linked with Ca2+ or Ba2+ and give a complementary insight into the spatial homogeneity of theCross-Linking process.