M.-J. Milloy

TL;DR: Whether the opening of an SIF in Vancouver, BC, Canada, was associated with a reduction in overdose mortality is sought and supervised injecting facilities should be considered where injection drug use is prevalent, particularly in areas with high densities of overdose.

TL;DR: The findings support improved adherence support for HIV-seropositive IDUs experiencing incarceration and an increasing burden of incarceration was associated with poorer adherence in a dose-dependent fashion.

TL;DR: It is demonstrated that MMT contributes to more rapid initiation and subsequent adherence to ART among opioid-using HIV-infected IDU, and addressing international barriers to the use and availability of methadone may increase dramatically uptake of HIV treatment among this population.

TL;DR: Based on a conservative estimate of the local ratio of non-fatal to fatal overdoses, the potentially fatal overdoses in the SIF during the study period could have resulted in between 8 and 51 deaths had they occurred outside the facility, or from 6% to 37% of the total overdose mortality burden in the neighborhood during theStudy period.

TL;DR: Sub-optimal ART adherence was associated with homelessness and daily injection heroin use among HIV-infected IDU and it is critical to develop and evaluate innovative strategies such as supportive housing and methadone maintenance to address these risk factors to improve adherence.