Institution
Vancouver Coastal Health
Healthcare•Vancouver, British Columbia, Canada•
About: Vancouver Coastal Health is a healthcare organization based out in Vancouver, British Columbia, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 1254 authors who have published 1559 publications receiving 43536 citations.
Papers published on a yearly basis
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TL;DR: The results show that a stratified approach, by use of prognostic screening with matched pathways, will have important implications for the future management of back pain in primary care.
1,089 citations
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TL;DR: In critically ill patients, intensive glucose control leads to moderate and severe hypoglycemia, both of which are associated with an increased risk of death, and the association exhibits a dose-response relationship and is strongest for death from distributive shock.
Abstract: Background: Whether hypoglycemia leads to death in critically ill patients is unclear.
Methods: We examined the associations between moderate and severe hypoglycemia (blood glucose, 41 to 70 mg per deciliter [2.3 to 3.9 mmol per liter] and ≤40 mg per deciliter [2.2 mmol per liter], respectively) and death among 6026 critically ill patients in intensive care units (ICUs). Patients were randomly assigned to intensive or conventional glucose control. We used Cox regression analysis with adjustment for treatment assignment and for baseline and postrandomization covariates.
Results: Follow-up data were available for 6026 patients: 2714 (45.0%) had moderate hypoglycemia, 2237 of whom (82.4%) were in the intensive-control group (i.e., 74.2% of the 3013 patients in the group), and 223 patients (3.7%) had severe hypoglycemia, 208 of whom (93.3%) were in the intensive-control group (i.e., 6.9% of the patients in this group). Of the 3089 patients who did not have hypoglycemia, 726 (23.5%) died, as compared with 774 of the 2714 with moderate hypoglycemia (28.5%) and 79 of the 223 with severe hypoglycemia (35.4%). The adjusted hazard ratios for death among patients with moderate or severe hypoglycemia, as compared with those without hypoglycemia, were 1.41 (95% confidence interval [CI], 1.21 to 1.62; P 1 day vs. 1 day, P=0.01), those who died from distributive (vasodilated) shock (P<0.001), and those who had severe hypoglycemia in the absence of insulin treatment (hazard ratio, 3.84; 95% CI, 2.37 to 6.23; P<0.001).
Conclusions: In critically ill patients, intensive glucose control leads to moderate and severe hypoglycemia, both of which are associated with an increased risk of death. The association exhibits a dose-response relationship and is strongest for death from distributive shock. However, these data cannot prove a causal relationship. (Funded by the Australian National Health and Medical Research Council and others; NICE-SUGAR ClinicalTrials.gov number, NCT00220987.).
822 citations
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TL;DR: A population-level association between increasing HAART coverage, decreased viral load, and decreased number of new HIV diagnoses per year is shown, which supports the proposed secondary benefit of HAART used within existing medical guidelines to reduce HIV transmission.
759 citations
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CEU San Pablo University1, National and Kapodistrian University of Athens2, University of Marburg3, Rush University Medical Center4, Toronto Western Hospital5, University of Toronto6, University of Pennsylvania7, Newcastle University8, University of New South Wales9, University of Sydney10, Centre national de la recherche scientifique11, Peking Union Medical College12, Columbia University13, University of Paris14, Aarhus University15, UCL Institute of Neurology16, National Institutes of Health17, Emory University18, San Francisco VA Medical Center19, University of California, San Francisco20, Veterans Health Administration21, Erasmus University Medical Center22, Baylor College of Medicine23, University of Kiel24, Hebrew University of Jerusalem25, University of Barcelona26, Columbia University Medical Center27, McGill University28, University of Alabama at Birmingham29, Northwestern University30, Icahn School of Medicine at Mount Sinai31, University of Perugia32, Vancouver Coastal Health33, University of British Columbia34
TL;DR: This multiple‐author article provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.
Abstract: This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.
523 citations
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University of British Columbia1, Columbia University2, California Institute of Technology3, McGill University4, Lafayette College5, National Radio Astronomy Observatory6, Goddard Space Flight Center7, Hillsdale College8, Cornell University9, Université de Montréal10, Vancouver Coastal Health11, West Virginia University12, University of Manchester13, University of New Mexico14, University of Wisconsin–Milwaukee15, Max Planck Society16
TL;DR: In this article, a wide range of binary pulsar masses and orbital inclination were derived from the NANOGrav nine-year data set, with values as low as {m}{m{p}{p}}}={1.41}{1.09}^{+0.10}
Abstract: We analyze 24 binary radio pulsars in the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) nine-year data set. We make 14 significant measurements of the Shapiro delay, including new detections in four pulsar-binary systems (PSRs J0613−0200, J2017+0603, J2302+4442, and J2317+1439), and derive estimates of the binary-component masses and orbital inclination for these MSP-binary systems. We find a wide range of binary pulsar masses, with values as low as ${m}_{{\rm{p}}}={1.18}_{-0.09}^{+0.10}\,{M}_{\odot }$ for PSR J1918−0642 and as high as ${m}_{{\rm{p}}}={1.928}_{-0.017}^{+0.017}\,{M}_{\odot }$ for PSR J1614−2230 (both 68.3% credibility). We make an improved measurement of the Shapiro timing delay in the PSR J1918−0642 and J2043+1711 systems, measuring the pulsar mass in the latter system to be ${m}_{{\rm{p}}}={1.41}_{-0.18}^{+0.21}\,{M}_{\odot }$ (68.3% credibility) for the first time. We measure secular variations of one or more orbital elements in many systems, and use these measurements to further constrain our estimates of the pulsar and companion masses whenever possible. In particular, we used the observed Shapiro delay and periastron advance due to relativistic gravity in the PSR J1903+0327 system to derive a pulsar mass of ${m}_{{\rm{p}}}={1.65}_{-0.02}^{+0.02}\,{M}_{\odot }$ (68.3% credibility). We discuss the implications that our mass measurements have on the overall neutron-star mass distribution, and on the "mass/orbital-period" correlation due to extended mass transfer.
450 citations
Authors
Showing all 1258 results
Name | H-index | Papers | Citations |
---|---|---|---|
David G. Huntsman | 122 | 486 | 58460 |
Margaret M. Esiri | 92 | 326 | 29452 |
C. Blake Gilks | 88 | 317 | 26761 |
Torsten O. Nielsen | 86 | 276 | 39385 |
Karim M. Khan | 82 | 352 | 23388 |
Michael Schulzer | 80 | 253 | 23340 |
Janice J. Eng | 76 | 300 | 19830 |
Lakshmi N. Yatham | 76 | 370 | 24219 |
Raymond W. Lam | 73 | 581 | 21813 |
B. Paul Morgan | 69 | 295 | 14556 |
Heather A. McKay | 69 | 291 | 16058 |
Thomas R. Oxland | 66 | 203 | 12946 |
Guy Faulkner | 64 | 450 | 20260 |
Jason Grebely | 63 | 345 | 15493 |
Marcel F. Dvorak | 63 | 281 | 12235 |