M
M J Orejarena
Researcher at Aix-Marseille University
Publications - 1
Citations - 106
M J Orejarena is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Dendritic spine & Long-term potentiation. The author has an hindex of 1, co-authored 1 publications receiving 94 citations. Previous affiliations of M J Orejarena include French Institute of Health and Medical Research & INMED.
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Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway
Jillian Iafrati,Jillian Iafrati,Jillian Iafrati,M J Orejarena,M J Orejarena,M J Orejarena,Olivier Lassalle,Olivier Lassalle,Olivier Lassalle,Lamine Bouamrane,Lamine Bouamrane,Lamine Bouamrane,Pascale Chavis,Pascale Chavis,Pascale Chavis +14 more
TL;DR: It is shown that reelin is essential for successful structural, functional and behavioral development of juvenile prefrontal circuits and that this developmental period provides a critical window for therapeutic rehabilitation with GluN2B-NMDAR antagonists and a single exposure to ketamine during the juvenile period reinstates normal fear memory in adolescent mice.