Jillian Iafrati

TL;DR: A class of lanthanide-doped imaging probes that harness an energy-looping mechanism that facilitates excitation at NIR-II wavelengths that are resonant with excited- state absorption transitions but not ground-state absorption are developed.

TL;DR: It is suggested that multiple forms of autism may alter the physiology of specific deep-layer prefrontal neurons that project to subcortical targets, and a highly overlapping population—prefrontal D2R+ neurons—plays an important role in both normal and abnormal social behavior, such that targeting these cells can elicit potentially therapeutic effects.

TL;DR: It is shown that reelin is essential for successful structural, functional and behavioral development of juvenile prefrontal circuits and that this developmental period provides a critical window for therapeutic rehabilitation with GluN2B-NMDAR antagonists and a single exposure to ketamine during the juvenile period reinstates normal fear memory in adolescent mice.

TL;DR: Using a series of molecular replacement experiments, the authors show that the kinase function of CaMKII is required for long-term plasticity and basal AMPA receptor-mediated transmission.

TL;DR: It is found that overexpression of DYRK1a largely increased the number of spines on oblique dendrites of pyramidal neurons, as evidenced by augmented spine density, higher PSD95 protein levels, and larger miniature EPSCs in adult mBACtgDyrk1a mice.