M
M Moore
Researcher at Princeton University
Publications - 5
Citations - 978
M Moore is an academic researcher from Princeton University. The author has contributed to research in topics: Gene & Mutant. The author has an hindex of 4, co-authored 5 publications receiving 929 citations.
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Journal ArticleDOI
Gain of function mutations in p53.
Dirk P. Dittmer,Sibani Pati,Gerard P. Zambetti,Shelley Chu,Angelika K. Teresky,M Moore,Cathy A. Finlay,Arnold J. Levine +7 more
TL;DR: These data demonstrate a gain of function associated with p53 mutations in addition to the loss of function shown previously to be associated with mutations in this tumour suppressor gene.
Journal ArticleDOI
Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells.
TL;DR: The hsp70 family of mRNAs can escape the transport block but not the translational block instituted late after adenovirus infection, and the beta-tubulin gene family is induced by the viral E1A gene after infection, so it seems likely that the process of transcriptional induction allows the resulting mRNA to escape the viral block of transport.
Journal ArticleDOI
p53 mutations are not selected for in simian virus 40 T-antigen-induced tumors from transgenic mice.
TL;DR: The hypothesis that T antigen inactivates the wild-type p53 tumor-suppressing activity and there is no need to select for mutations at the p53 locus is strongly supported.
Journal ArticleDOI
The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells
M Moore,Thomas Shenk +1 more
TL;DR: The tripartite leader stabilized the non-adenovirus mRNA only within the environment of an adenovirus-infected cell during the late phase of the infectious cycle.