M. Richard Sayen

TL;DR: Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death.

TL;DR: A method to measure autophagic flux in vivo even in non-transgenic animals, using MDC and chloroquine is described, validating its use as a marker of autophagosomes.

TL;DR: The preferential detection of the lipidated form of LC3 protein (LC3 II) in released EMVs harboring infectious virus suggests that the autophagy pathway plays a crucial role in microvesicle shedding and virus release, similar to a process previously described as autophagosome-mediated exit without lysis observed during poliovirus replication.

TL;DR: The finding that chloramphenicol administered at reperfusion reduced infarct size by 60% in a Langendorff isolated perfused rat heart model, and that ROS production was also substantially reduced, implicate CYPs in myocardial ischemia/reperfusion injury.

TL;DR: TAT-ARC was able to protect H9c2 cells against cell death mediated by hydrogen peroxide, as measured by protection against the loss of mitochondrial membrane potential and preservation of nuclear morphology, and was cardioprotective when administered before global ischemia and reperfusion.