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Eri Iwai-Kanai
Researcher at Tenri Health Care University
Publications - 41
Citations - 2674
Eri Iwai-Kanai is an academic researcher from Tenri Health Care University. The author has contributed to research in topics: Myocyte & Apoptosis. The author has an hindex of 23, co-authored 41 publications receiving 2344 citations. Previous affiliations of Eri Iwai-Kanai include Kyoto Prefectural University & Meiji University of Integrative Medicine.
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Journal ArticleDOI
Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
Atsushi Hoshino,Yuichiro Mita,Yoshifumi Okawa,Makoto Ariyoshi,Eri Iwai-Kanai,Eri Iwai-Kanai,Tomomi Ueyama,Koji Ikeda,Takehiro Ogata,Satoaki Matoba +9 more
TL;DR: It is shown that cytosolic p53 binds to Parkin and disturbs its translocation to damaged mitochondria and their subsequent clearance by mitophagy and overexpression of Parkin ameliorates the functional decline in aged hearts, and is accompanied by decreased senescence-associated β-galactosidase activity and proinflammatory phenotypes.
Journal ArticleDOI
A method to measure cardiac autophagic flux in vivo
Eri Iwai-Kanai,Hua Yuan,Chengqun Huang,M. Richard Sayen,Cynthia N. Perry-Garza,Lucy Kim,Roberta A. Gottlieb +6 more
TL;DR: A method to measure autophagic flux in vivo even in non-transgenic animals, using MDC and chloroquine is described, validating its use as a marker of autophagosomes.
Journal ArticleDOI
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
Hua Yuan,Cynthia N. Perry,Chengqun Huang,Eri Iwai-Kanai,Raquel S. Carreira,Christopher C. Glembotski,Roberta A. Gottlieb +6 more
TL;DR: The notion that autophagy is a cytoprotective response to LPS-induced cardiomyocyte injury is supported; additional studies are needed to determine the therapeutic implications.
Journal ArticleDOI
α- and β-Adrenergic Pathways Differentially Regulate Cell Type–Specific Apoptosis in Rat Cardiac Myocytes
Eri Iwai-Kanai,Koji Hasegawa,Makoto Araki,Tsuyoshi Kakita,Tatsuya Morimoto,Shigetake Sasayama +5 more
TL;DR: C cultured neonatal rat cardiac myocytes were characterized by cell shrinkage and nuclear condensation, consistent with morphological features of apoptosis, and Iso and 8-Br-cAMP markedly increased the number of TUNEL-positive cells compared with saline stimulation.
Journal ArticleDOI
Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes
Atsushi Hoshino,Makoto Ariyoshi,Yoshifumi Okawa,Satoshi Kaimoto,Motoki Uchihashi,Kuniyoshi Fukai,Eri Iwai-Kanai,Eri Iwai-Kanai,Koji Ikeda,Tomomi Ueyama,Takehiro Ogata,Satoaki Matoba +11 more
TL;DR: It is found that genetic and pharmacological inhibition of p53 preserves insulin secretion and glucose tolerance in both streptozotocin-induced type 1 and db/db mouse models of type 2 diabetes.