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Nicole H. Purcell
Researcher at University of California, San Diego
Publications - 23
Citations - 3944
Nicole H. Purcell is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Signal transduction & RHOA. The author has an hindex of 18, co-authored 22 publications receiving 3538 citations. Previous affiliations of Nicole H. Purcell include Boston Children's Hospital & Cincinnati Children's Hospital Medical Center.
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Journal ArticleDOI
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Christopher P. Baines,Robert A. Kaiser,Nicole H. Purcell,N. Scott Blair,Hanna Osinska,Michael Hambleton,Eric W. Brunskill,M. Richard Sayen,Roberta A. Gottlieb,Gerald W. Dorn,Jeffrey Robbins,Jeffery D. Molkentin +11 more
TL;DR: Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca2+- and oxidative damage-induced cell death, but not Bcl-2 family member-regulated death.
Journal ArticleDOI
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo
Nicole H. Purcell,Benjamin J. Wilkins,Allen J. York,Marc K. Saba-El-Leil,Sylvain Meloche,Jeffrey Robbins,Jeffery D. Molkentin +6 more
TL;DR: Blockage or deletion of cardiac ERK1/2 did predispose the heart to decompensation and failure after long-term pressure overload in conjunction with an increase in myocyte TUNEL, but ERK 1/2 signaling is not required for mediating physiologic or pathologic cardiac hypertrophy in vivo, although it does play a protective role in response to pathologic stimuli.
Journal ArticleDOI
MEK1-ERK2 Signaling Pathway Protects Myocardium From Ischemic Injury In Vivo
Daniel J. Lips,Orlando F. Bueno,Benjamin J. Wilkins,Nicole H. Purcell,Robert A. Kaiser,John N. Lorenz,Laure Voisin,Marc K. Saba-El-Leil,Sylvain Meloche,Jacques Pouysségur,Gilles Pagès,Leon J. De Windt,Pieter A. Doevendans,Jeffery D. Molkentin +13 more
TL;DR: These data are the first to demonstrate that ERK2 signaling is required to protect the myocardium from ischemia-reperfusion injury in vivo.
Journal ArticleDOI
APJ acts as a dual receptor in cardiac hypertrophy
Maria Cecilia Scimia,Cecilia Hurtado,Saugata Ray,Scott A. Metzler,Ke Wei,Jianming Wang,Christopher E. Woods,Nicole H. Purcell,Daniele Catalucci,Takeshi Akasaka,Orlando F. Bueno,George P. Vlasuk,Perla Kaliman,Rolf Bodmer,Layton H. Smith,Euan A. Ashley,Mark Mercola,Joan Heller Brown,Pilar Ruiz-Lozano,Pilar Ruiz-Lozano +19 more
TL;DR: It is reported that genetic loss of APJ, a G-protein-coupled receptor, confers resistance to chronic pressure overload by markedly reducing myocardial hypertrophy and heart failure, and indicates that APJ is a bifunctional receptor for both mechanical stretch and the endogenous peptide apelin.
Journal ArticleDOI
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility.
Marjorie Maillet,Nicole H. Purcell,Michelle A. Sargent,Allen J. York,Orlando F. Bueno,Jeffery D. Molkentin +5 more
TL;DR: The results demonstrate that ERK1/2 signaling is physiologically restrained by DUSP6 in coordinating cellular development and survival characteristics, directly impacting disease-responsiveness in adulthood.