M
M. van Iersel
Researcher at Netherlands Organisation for Applied Scientific Research
Publications - 22
Citations - 305
M. van Iersel is an academic researcher from Netherlands Organisation for Applied Scientific Research. The author has contributed to research in topics: Glutathione & Wireless sensor network. The author has an hindex of 8, co-authored 20 publications receiving 287 citations.
Papers
More filters
Journal ArticleDOI
Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
M. van Iersel,J.H.T.M. Ploemen,I. Struik,C. van Amersfoort,A.E. Keyzer,J.G. Schefferlie,P.J. van Bladeren +6 more
TL;DR: Reversible inhibition of GST was the major mechanism of inhibition of DNPSG-excretion in melanoma cells, except in the cases of curcumin and ethacrynic acid, which compounds also inactivated GSTP1-1 by covalent modification.
Journal ArticleDOI
The role of biotransformation in dietary (anti)carcinogenesis
TL;DR: For certain constituents it is acknowledged that they have anticarcinogenic properties, which provides for an important mechanistic substantiation of the established cancer chemopreventive effect of a diet rich in fruits and vegetables.
Journal ArticleDOI
Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
TL;DR: PGA2 modulates all three aspects of the glutathione-mediated biotransformation system, i.e. GSH levels, GSTP1-1 activity, and transport of GSH conjugates.
Journal ArticleDOI
In Vitro Inhibition of Rat and Human Glutathione S-Transferase Isoenzymes by Disulfiram and Diethyldithiocarbamate
J.H.T.M. Ploemen,M. van Iersel,L.W. Wormhoudt,Jan N. M. Commandeur,Nico P. E. Vermeulen,P.J. van Bladeren +5 more
TL;DR: The rat and human pi-class was, by far, the most sensitive class for time-dependent inactivation by DSF, but no such inactivation was observed for any of the GSTs by DDTC.
Journal ArticleDOI
Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat.
TL;DR: The biotransformation of HCB and PCBz was modulated by selective inhibition of cytochrome P450IIIA in rats which received combined treatment of H CB or PCBz with triacetyloleandomycin (TAO) and rats receiving this diet had a strongly diminished excretion of both PCP and TCHQ, indicating the involvement of P450 IIIA in the oxidation of both compounds.