M. van Vugt

TL;DR: In this area of low malaria transmission, early diagnosis and treatment with combined artesunate and me floquine has reduced the incidence of P. falciparum malaria and halted the progression of mefloquine resistance.

TL;DR: Lumefantrine oral bioavailability is very dependent on food and is consequently poor in acute malaria but improves markedly with recovery, and the high cure rates with the two six-dose regimens resulted from increased AUC and increased time at which lumefanrine concentrations were above the in vivo MIC.

TL;DR: Characterisation of these pharmacokinetic-pharmacodynamic relationships provided the basis for dosage optimisation, an approach that could be applied to other antimalarial drugs.

TL;DR: The relationship between pfmdr1 and resistance to structurally distinct antimalarial agents confirms the presence of a true multidrug-resistant phenotype.

TL;DR: In a prospective study of acute uncomplicated, multidrug-resistant falciparum malaria on the western border of Thailand, the oral artemisinin derivatives were used alone in the treatment of 836 patients (artesunate 630, artemether 206), were combined with mefloquine (15-25 mg base/kg) in 2,826 patients, and me floquine alone was used in 1,303 patients as discussed by the authors.