M
Manoj T. Duraisingh
Researcher at Harvard University
Publications - 192
Citations - 12397
Manoj T. Duraisingh is an academic researcher from Harvard University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 56, co-authored 175 publications receiving 10980 citations. Previous affiliations of Manoj T. Duraisingh include Brigham and Women's Hospital & University of Dundee.
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Journal ArticleDOI
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
Cécile Crosnier,Leyla Y. Bustamante,S. Josefin Bartholdson,Amy K. Bei,Michel Theron,Makoto Uchikawa,Souleymane Mboup,Omar Ndir,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Manoj T. Duraisingh,Julian C. Rayner,Gavin J. Wright +12 more
TL;DR: The discovery of a cross-strain dependency on a single extracellular receptor–ligand pair for erythrocyte invasion by P. falciparum provides a focus for new anti-malarial therapies.
Journal ArticleDOI
Heterochromatin Silencing and Locus Repositioning Linked to Regulation of Virulence Genes in Plasmodium falciparum
Manoj T. Duraisingh,Till S. Voss,Allison J. Marty,Allison J. Marty,Michael F. Duffy,Robert T. Good,Jennifer K. Thompson,Lucio H. Freitas-Junior,Artur Scherf,Brendan S. Crabb,Alan F. Cowman +10 more
TL;DR: It is demonstrated that both a subtelomeric transgene and var genes are subject to reversible gene silencing, which implies that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in P. falciparum.
Journal ArticleDOI
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.
Alexander G. Maier,Manoj T. Duraisingh,John C. Reeder,Sheral S. Patel,James W. Kazura,Peter A. Zimmerman,Alan F. Cowman +6 more
TL;DR: It is shown that the receptor for EBA140 is glycophorin C (GYPC) and that this interaction mediates a principal P. falciparum invasion pathway into human erythrocytes, providing compelling evidence that Ge negativity has arisen in Melanesian populations through natural selection by severe malaria.
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A genome-wide map of diversity in Plasmodium falciparum.
Sarah K. Volkman,Pardis C. Sabeti,David DeCaprio,Daniel E. Neafsey,Stephen F. Schaffner,Danny A. Milner,Johanna P. Daily,Ousmane Sarr,Daouda Ndiaye,Omar Ndir,S. Mboup,Manoj T. Duraisingh,Amanda K. Lukens,Alan Derr,Nicole Stange-Thomann,Skye G. Waggoner,Robert C. Onofrio,Liuda Ziaugra,Evan Mauceli,Sante Gnerre,David B. Jaffe,Joanne Zainoun,Roger C. Wiegand,Bruce W. Birren,Daniel L. Hartl,James E. Galagan,Eric S. Lander,Dyann F. Wirth,Dyann F. Wirth +28 more
TL;DR: An initial survey of genetic variation across the P. falciparum genome is described and its potential utility in identifying genes subject to recent natural selection and in understanding the population genetics of this parasite is demonstrated.
Journal ArticleDOI
A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
Jeffrey D. Dvorin,Jeffrey D. Dvorin,Derek C. Martyn,Saurabh D. Patel,Saurabh D. Patel,Joshua S. Grimley,Christine R. Collins,Christine S. Hopp,A. Taylor Bright,Scott J. Westenberger,Elizabeth A. Winzeler,Elizabeth A. Winzeler,Michael J. Blackman,David A. Baker,Thomas J. Wandless,Manoj T. Duraisingh +15 more
TL;DR: It is found that the plant-like calcium-dependent protein kinase PfCDPK5, which is expressed in invasive merozoite forms of Plasmodium falciparum, was critical for egress from the human host erythrocyte, an essential step in the parasite life cycle.