M
M.W. Büchler
Researcher at Heidelberg University
Publications - 703
Citations - 28418
M.W. Büchler is an academic researcher from Heidelberg University. The author has contributed to research in topics: Pancreatitis & Pancreatic cancer. The author has an hindex of 67, co-authored 696 publications receiving 25796 citations. Previous affiliations of M.W. Büchler include University Hospital Heidelberg & University of Bern.
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Journal ArticleDOI
Postoperative pancreatic fistula: an international study group (ISGPF) definition.
Claudio Bassi,Christos Dervenis,Giovanni Butturini,Abe Fingerhut,Charles J. Yeo,Jakob R. Izbicki,John P. Neoptolemos,Michael G. Sarr,William Traverso,M.W. Büchler +9 more
TL;DR: In this article, an international panel of pancreatic surgeons, working in well-known, high-volume centers, reviewed the literature on the topic and worked together to develop a simple, objective, reliable, and easy-to-apply definition of postoperative pancreatic fistula, graded primarily on clinical impact.
Special article Postoperative pancreatic fistula: An international study group (ISGPF) definition
Claudio Bassi,Christos Dervenis,Giovanni Butturini,Abe Fingerhut,Jakob R. Izbicki,John P. Neoptolemos,Michael G. Sarr,William Traverso,M.W. Büchler +8 more
TL;DR: The present definition and clinical grading of POPF should allow realistic comparisons of surgical experiences in the future when new techniques, new operations, or new pharmacologic agents that may impact surgical treatment of pancreatic disorders are addressed.
Journal ArticleDOI
The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula : 11 Years After
Claudio Bassi,Giovanni Marchegiani,Christos Dervenis,Sarr Mg,Mohammad Abu Hilal,Mustapha Adam,Peter J. Allen,Roland Andersson,Horacio J. Asbun,Marc G. Besselink,Kevin C. Conlon,Marco Del Chiaro,Massimo Falconi,Laureano Fernández-Cruz,Carlos Fernandez-del Castillo,Abe Fingerhut,Helmut Friess,Dirk J. Gouma,Thilo Hackert,Jakob R. Izbicki,Keith D. Lillemoe,John P. Neoptolemos,Attila Oláh,Richard D. Schulick,Shailesh V. Shrikhande,Tadahiro Takada,Kyoichi Takaori,William Traverso,C. Vollmer,Christopher L. Wolfgang,Charles J. Yeo,Roberto Salvia,M.W. Büchler +32 more
TL;DR: This new definition and grading system of postoperative pancreatic Fistula should lead to a more universally consistent evaluation of operative outcomes after pancreatic operation and will allow for a better comparison of techniques used to mitigate the rate and clinical impact of a pancreatic fistula.
Journal ArticleDOI
Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells.
Minoti V. Apte,S Park,Phoebe A. Phillips,N. Santucci,David Goldstein,Rakesh K. Kumar,Grant A. Ramm,M.W. Büchler,Helmut Friess,Joshua A. McCarroll,Gregory W Keogh,Neil D. Merrett,Ron Pirola,Jeremy S. Wilson +13 more
TL;DR: Activated PSCs are present in theStromal reaction in pancreatic cancers and are responsible for the production of stromal collagen.
Journal Article
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial
John P. Neoptolemos,Malcolm J. Moore,Trevor Cox,Juan W. Valle,Daniel H. Palmer,Alec McDonald,Rodney William Carter,Niall C. Tebbutt,Christos Dervenis,D. Smith,Bengt Glimelius,Richard Charnley,François Lacaine,Scarfe Ag,Middleton,Alan Anthoney,Paula Ghaneh,Christopher Halloran,Markus M. Lerch,Attila Oláh,Charlotte L. Rawcliffe,Caroline S. Verbeke,Fiona Campbell,M.W. Büchler +23 more
TL;DR: Among patients with resected periampullary adenocarcinoma, adjuvant chemotherapy, compared with observation, was not associated with a significant survival Benefit in the primary analysis; however, multivariable analysis adjusting for prognostic variables demonstrated a statistically significant survival benefit associated with adjuant chemotherapy.