M
M. W. Edwards
Researcher at National Institutes of Health
Publications - 14
Citations - 1352
M. W. Edwards is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Binding site & Cyclase. The author has an hindex of 11, co-authored 14 publications receiving 1335 citations.
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Journal ArticleDOI
Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog
Thomas F. Spande,H. M. Garraffo,M. W. Edwards,Herman J. C. Yeh,Lewis K. Pannell,John W. Daly +5 more
TL;DR: A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane represents a unique new class of alkaloids.
Journal ArticleDOI
Widespread occurrence in frogs and toads of skin compounds interacting with the ouabain site of Na+, K+-ATPase.
TL;DR: Skin extracts from 30 of 48 species of frogs representing an additional eight families contained relatively low levels of compounds that inhibit binding of ouabain to Na+,K+-adenosinetriphosphatase.
Journal ArticleDOI
Binding of [3H]forskolin to rat brain membranes.
TL;DR: It is proposed that the high-affinity binding sites for forskolin are associated with the activated complex of catalytic subunit and stimulatory guanine nucleotide binding protein.
Binding of 3H-forskolin to rat brain membranes
TL;DR: In this article, forskolin was used to study binding sites in rat brain tissue by using both centrifugation and filtration assays, and the results showed that the high affinity binding sites were associated with the activated complex of catalytic subunit and stimulatory guanine nucleotide binding protein.
Journal ArticleDOI
Alkaloids from a panamanian poison frog, Dendrobates speciosus: identification of pumiliotoxin-A and allopumiliotoxin class alkaloids, 3,5-disubstituted indolizidines, 5-substituted 8-methylindolizidines, and a 2-methyl-6-nonyl-4-hydroxypiperidine.
TL;DR: Gc-ms analysis indicated the presence of at least 30 alkaloids in MeOH skin extracts from population samples at the extreme eastern end of the known geographic range, which confirmed their identity with alkaloid known from other species and in other cases led to assignment of structures.