Maddalena Pizzulo

TL;DR: There is evidence that DEPDC7 may be required to specifically convey on the CBM complex signals coming from activated G protein-coupled receptors, and evidence that shRNA-mediated abrogation of DE PDC7 results in impaired NF-κB activation.

TL;DR: It is demonstrated that in human keratinocytes CARMA2sh plays an essential role in the signal transduction pathway that connects pathogen-associated molecular patterns recognition to NF-κB activation, and a peptide blocking CARD-mediated BCL10 interactions reduces the capacity of psoriasis-linked CARma2sh mutants to activate NF-γB.

TL;DR: The functional characterization of a Danio rerio 241 amino acids polypeptide ortholog of the Caspase recruiting domain (CARD)-containing protein BCL10 shows that zebrafish may excellently serve as a model organism to study complex and intricate signal transduction pathways, such as those that control NF-κB activation.

TL;DR: Findings identify a new mechanism through which the ability of CARMA2 to activate NF-κB is regulated, which could have significant implications for the understanding of why mutations of this protein trigger human psoriasis.

TL;DR: Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action as discussed by the authors.