S
Sabrina Dallavalle
Researcher at University of Milan
Publications - 187
Citations - 3098
Sabrina Dallavalle is an academic researcher from University of Milan. The author has contributed to research in topics: Camptothecin & Chemistry. The author has an hindex of 27, co-authored 176 publications receiving 2496 citations. Previous affiliations of Sabrina Dallavalle include Mario Negri Institute for Pharmacological Research & Savitribai Phule Pune University.
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Development and therapeutic impact of HDAC6-selective inhibitors
TL;DR: The emerging interest for HDAC6-selective inhibitors is related to the modulation of acetylation of nonhistone regulatory proteins implicated in cancer-relevant processes, including cell migration, metastasis, angiogenesis and stress-response pathways.
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Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.
Sabrina Dallavalle,Vladimir Dobričić,Loretta Lazzarato,Elena Gazzano,Miguel Machuqueiro,Ilza Pajeva,Ivanka Tsakovska,Nace Zidar,Roberta Fruttero +8 more
TL;DR: Promising recent approaches that have been developed with the aim of circumventing or overcoming MDR are explored, including the pharmaco-modulation of acridine, the use of natural compounds as means to reverse MDR, and the conjugation of anticancer drugs with carriers that target specific tumor-cell components.
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An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities
TL;DR: This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches.
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Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity
Sabrina Dallavalle,Anna Maria Ferrari,Barbara Biasotti,Lucio Merlini,Sergio Penco,Grazia Gallo,Mauro Marzi,Tinti Maria Ornella,Roberta Martinelli,Claudio Pisano,Paolo Carminati,Nives Carenini,Giovanni Luca Beretta,Paola Perego,Michelandrea De Cesare,and Graziella Pratesi,Franco Zunino +16 more
TL;DR: Investigation of the DNA-Topo I-drug cleavable complex showed a rough parallelism between cytotoxicity and inhibition of Topo I, and persistence of theDNA cleavage after NaCl-mediated disruption of the ternary complex suggests that for the most potent compounds, e.g., 15, the cytotoxic activity was at least in part related to stabilization of the complex.
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Autopoietic self-reproduction of chiral fatty acid vesicles
TL;DR: In this paper, the self-reproduction of vesicles formed by (S)- and (R)-2-methyldodecanoic acid (4) was investigated in order to relate the autocatalytic increase of the vesicle concentration with enantioselectivity.