M
Magali Iché
Researcher at French Institute of Health and Medical Research
Publications - 5
Citations - 424
Magali Iché is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Gene isoform & Excitatory postsynaptic potential. The author has an hindex of 5, co-authored 5 publications receiving 396 citations. Previous affiliations of Magali Iché include Aix-Marseille University.
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Journal ArticleDOI
Decreasing Glutamate Buffering Capacity Triggers Oxidative Stress and Neuropil Degeneration in the Drosophila Brain
Thomas Rival,Laurent Soustelle,Colette Strambi,Marie-Thérèse Besson,Magali Iché,Serge Birman +5 more
TL;DR: It is shown that decreasing glutamate buffering capacity is neurotoxic in Drosophila and that the dEAAT1-deficient fly provides a powerful genetic model system for molecular analysis of glutamate-mediated neurodegeneration.
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Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
TL;DR: In vivo evidence is provided that expanded polyQ peptides antagonize epidermal growth factor receptor (EGFR) signaling in Drosophila glia, suggesting that disruption of EGFR signaling and ensuing glial cell dysfunction could play a direct role in the pathogenesis of HD and other polyQ diseases in humans.
Journal ArticleDOI
Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms.
TL;DR: It is shown that the embryonic lethality of ple can be rescued by expression of the hypodermal, but not the neural, DTH isoform in all DA cells, indicating that the hypoderm‐ isoform is absolutely required for cuticle biosynthesis and survival in Drosophila.
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Physiological requirement for the glutamate transporter dEAAT1 at the adult Drosophila neuromuscular junction.
TL;DR: The lack of dEAAT1 prolonged the duration of the individual responses to motor nerve stimulation and this effect was progressively increased during physiological trains of stimulations, suggesting that glutamate reuptake by glial cells is required to ensure normal activity of the Drosophila NMJ, but only in adult flies.