L
Laurent Soustelle
Researcher at French Institute of Health and Medical Research
Publications - 19
Citations - 760
Laurent Soustelle is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Nervous system & Cellular differentiation. The author has an hindex of 16, co-authored 18 publications receiving 697 citations. Previous affiliations of Laurent Soustelle include Centre national de la recherche scientifique.
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Journal ArticleDOI
Decreasing Glutamate Buffering Capacity Triggers Oxidative Stress and Neuropil Degeneration in the Drosophila Brain
Thomas Rival,Laurent Soustelle,Colette Strambi,Marie-Thérèse Besson,Magali Iché,Serge Birman +5 more
TL;DR: It is shown that decreasing glutamate buffering capacity is neurotoxic in Drosophila and that the dEAAT1-deficient fly provides a powerful genetic model system for molecular analysis of glutamate-mediated neurodegeneration.
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Dual mechanism for bitter avoidance in Drosophila.
Alice Sarah French,Alice Sarah French,Alice Sarah French,Marie-Jeanne Sellier,Marie-Jeanne Sellier,Moutaz Ali Agha,Moutaz Ali Agha,Alexandra M. A. Guigue,Alexandra M. A. Guigue,Marie-Ange Chabaud,Pablo Reeb,Aniruddha Mitra,Yves Grau,Yves Grau,Laurent Soustelle,Laurent Soustelle,Frédéric Marion-Poll,Frédéric Marion-Poll,Frédéric Marion-Poll +18 more
TL;DR: It is postulate that sugar-sensing inhibition represents a mechanism in insects to prevent ingesting harmful substances occurring within mixtures and that it affects taste cells on the proboscis and the legs.
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Physiological requirement for the glutamate transporter dEAAT1 at the adult Drosophila neuromuscular junction.
TL;DR: The lack of dEAAT1 prolonged the duration of the individual responses to motor nerve stimulation and this effect was progressively increased during physiological trains of stimulations, suggesting that glutamate reuptake by glial cells is required to ensure normal activity of the Drosophila NMJ, but only in adult flies.
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Selective high-affinity transport of aspartate by a Drosophila homologue of the excitatory amino-acid transporters
TL;DR: dEAAT2 - a nervous tissue-specific EAAT homologue that was recently identified in the fruit fly Drosophila - is a selective Na(+)-dependent high-affinity aspartate transporter, the first known EAAT to show this substrate selectivity.
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Terminal Glial Differentiation Involves Regulated Expression of the Excitatory Amino Acid Transporters in the Drosophila Embryonic CNS
TL;DR: The results show that glia play a major role in excitatory amino acid transport in the Drosophila CNS and that regulated expression of the dEAAT genes contributes to generate the functional diversity of glial cells during embryonic development.