R
Robert J. Homer
Researcher at Yale University
Publications - 228
Citations - 25774
Robert J. Homer is an academic researcher from Yale University. The author has contributed to research in topics: Inflammation & Interleukin 13. The author has an hindex of 77, co-authored 216 publications receiving 22910 citations. Previous affiliations of Robert J. Homer include Northwestern University & Veterans Health Administration.
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Journal ArticleDOI
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
Zhou Zhu,Robert J. Homer,Robert J. Homer,Zhonde Wang,Qingsheng Chen,Gregory P. Geba,Gregory P. Geba,Jingming Wang,Yong Zhang,Jack A. Elias +9 more
TL;DR: The targeted pulmonary expression of IL-13 causes a mononuclear and eosinophilic inflammatory response, mucus cell metaplasia, airway fibrosis, eotaxin production, airways obstruction, and nonspecific AHR in transgene-positive animals.
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Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Dianhua Jiang,Jiurong Liang,Juan Fan,Shuang Yu,Suping Chen,Yi Luo,Glenn D. Prestwich,Marcella M. Mascarenhas,Hari G. Garg,Deborah A. Quinn,Robert J. Homer,Daniel R. Goldstein,Richard Bucala,Patty J. Lee,Ruslan Medzhitov,Paul W. Noble +15 more
TL;DR: It is reported that hyaluronan degradation products require MyD88 and both Toll-like receptor (TLR)4 and TLR2 in vitro and in vivo to initiate inflammatory responses in acute lung injury and epithelial cell apoptosis after lung injury.
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Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1
Chun Geun Lee,Robert J. Homer,Zhou Zhu,Sophie Lanone,Xiaoman Wang,Victor Koteliansky,J. Michael Shipley,Philip Gotwals,Paul W. Noble,Qingsheng Chen,Robert M. Senior,Jack A. Elias +11 more
TL;DR: It is demonstrated that IL-13 is a potent stimulator and activator of TGF-β1 in vivo and that this activation is mediated by a plasmin/serine protease- and MMP-9–dependent and CD44-independent mechanism and that the fibrogenic effects of IL- 13 are mediated, in great extent, by this T GF-β pathway.
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Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhou Zhu,Tao Zheng,Robert J. Homer,Yoon Keun Kim,Ning Yuan Chen,Lauren Cohn,Qutayba Hamid,Jack A. Elias +7 more
TL;DR: It is shown that acidic mammalian chitinase (AMCase) is induced via a T helper-2 (Th2)–specific, interleukin-13 (IL-13)–mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model and expressed in exaggerated quantities in human asthma.
Journal ArticleDOI
Airway remodeling in asthma.
TL;DR: The prevalence, morbidity, and mortality of asthma have increased since the 1980s, and is the most frequent reason for preventable childhood hospitalizations in the United States.