P
Peter S. DiStefano
Researcher at Millennium Pharmaceuticals
Publications - 115
Citations - 21327
Peter S. DiStefano is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Neurotrophic factors & Neurotrophin. The author has an hindex of 60, co-authored 113 publications receiving 20518 citations. Previous affiliations of Peter S. DiStefano include Regeneron & Thomas Jefferson University.
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Journal ArticleDOI
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Stephen E. Girardin,Ivo G. Boneca,Leticia A.M. Carneiro,Aude Antignac,Muguette Jéhanno,Jérôme Viala,Karsten Tedin,Muhamed-Kheir Taha,Agnès Labigne,Ulrich Zähringer,Anthony J. Coyle,Peter S. DiStefano,John Bertin,Philippe J. Sansonetti,Dana J. Philpott +14 more
TL;DR: It is shown that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine–N-acetelmuramic acid tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-κB pathway.
Journal ArticleDOI
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Jérôme Viala,Catherine Chaput,Ivo G Boneca,Ana Cardona,Stephen E. Girardin,Anthony P. Moran,Rafika Athman,Sylvie Mémet,Michael R Huerre,Anthony J. Coyle,Peter S. DiStefano,Philippe J. Sansonetti,A Labigne,John Bertin,Dana J. Philpott,Dana J. Philpott,Richard L. Ferrero,Richard L. Ferrero +17 more
TL;DR: It is proposed that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens as well as an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan.
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Thomas M. DeChiara,David C. Bowen,David M. Valenzuela,Mary V. Simmons,William Poueymirou,Susan Thomas,Erika Kinetz,Debra L Compton,Rojas Eduardo A,John S. Park,Cynthia L. Smith,Peter S. DiStefano,David J. Glass,Steven J. Burden,George D. Yancopoulos +14 more
TL;DR: It is indicated that MuSK responds to a critical nerve-derived signal (agrin), and in turn activates signaling cascades responsible for all aspects of synapse formation, including organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation.
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DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
Hien Tran,Anne Brunet,Jill M. Grenier,Sandeep Robert Datta,Albert J. Fornace,Peter S. DiStefano,Lillian W. Chiang,Michael E. Greenberg +7 more
TL;DR: Findings indicate that in mammals FOXO3a regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life-span.
Journal ArticleDOI
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Stephen P. Squinto,Trevor Stitt,Aldrich Thomas H,Samuel Davis,Stella M. Blanco,Czeslaw Radziejewski,David J. Glass,Piotr Masiakowski,Mark E. Furth,David M. Valenzuela,Peter S. DiStefano,George D. Yancopoulos +11 more
TL;DR: It is demonstrated that all three of these neuronal survival molecules bind similarly to the low affinity NGF receptor, but that BDNF and NT-3, unlike NGF, do not act via the high affinity N GF receptor.