M
Magnus Bäcklund
Researcher at Karolinska Institutet
Publications - 13
Citations - 1108
Magnus Bäcklund is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Tamoxifen & Cancer. The author has an hindex of 6, co-authored 9 publications receiving 928 citations.
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Journal ArticleDOI
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
Marcel Kool,Andrey Korshunov,Marc Remke,Marc Remke,David T.W. Jones,Maria Schlanstein,Paul A. Northcott,Yoon Jae Cho,Jan Koster,Antoinette Y N Schouten-van Meeteren,Dannis G. van Vuurden,Steven C. Clifford,Torsten Pietsch,André O. von Bueren,Stefan Rutkowski,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Magnus Bäcklund,Christine Haberler,Franck Bourdeaut,Olivier Delattre,François Doz,David W. Ellison,Richard J. Gilbertson,Scott L. Pomeroy,Michael D. Taylor,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +29 more
TL;DR: A meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies shows how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival.
Journal ArticleDOI
Improved grading and survival prediction of human astrocytic brain tumors by artificial neural network analysis of gene expression microarray data
Lawrence P. Petalidis,Anastasis Oulas,Magnus Bäcklund,Matthew T. Wayland,Lu Liu,Karen Plant,Lisa Happerfield,Tom C. Freeman,Panayiota Poirazi,V. Peter Collins +9 more
TL;DR: The prognostic value of the three identified tumor sub types was found to outperform histopathologic grading as well as tumor subtypes reported in other studies, indicating a high survival prognostic potential for the 59 gene classifiers.
Journal ArticleDOI
High prevalence of human cytomegalovirus in brain metastases of patients with primary breast and colorectal cancers.
Chato Taher,Gabriella Frisk,Stina Fuentes,Piotr Religa,Helena Costa,Alice Assinger,Katja Vetvik,Ida Rashida Khan Bukholm,Koon-Chu Yaiw,Karin E. Smedby,Magnus Bäcklund,Cecilia Söderberg-Nauclér,Afsar Rahbar +12 more
TL;DR: The prevalence of HCMV proteins and nucleic acids is very high in primary and metastatic tumors and may drive the development of metastatic brain tumors; therefore, this virus may represent a potential therapeutic target in metastatic cancer.
Journal ArticleDOI
Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells.
Mia Carapancea,Daria Cosaceanu,Raluca Budiu,Anna Kwiecinska,Ligia Gabriela Tataranu,Vasile Ciubotaru,Oana Alexandru,Monica Banita,Cătălina Gabriela Pisoschi,Magnus Bäcklund,Rolf Lewensohn,Anica Dricu +11 more
TL;DR: Co-expression of Insulin like growth factor-1 receptor (IGF-1R) and platelet derived growth factor receptor (PDGFR) and co-inhibition in two high-grade gliomas (HGG) cell lines 18 and 38 caused an increased cell death and induced the radiosensitization of the JNK1 expressing cell line.
Journal ArticleDOI
Growth factor receptors signaling in glioblastoma cells: therapeutic implications
Mia Carapancea,Oana Alexandru,Ani S. Fetea,Laura Dragutescu,Juan Castro,Ada Maria Georgescu,Aurel Popa-Wagner,Magnus Bäcklund,Rolf Lewensohn,Anica Dricu +9 more
TL;DR: The results showed that GB cells are in general resistant to treatment and illustrate the difficulties in predicting the treatment response in malignant gliomas.