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Yoon Jae Cho
Researcher at Oregon Health & Science University
Publications - 116
Citations - 21682
Yoon Jae Cho is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Medulloblastoma & Cancer. The author has an hindex of 50, co-authored 112 publications receiving 18376 citations. Previous affiliations of Yoon Jae Cho include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
The landscape of somatic copy-number alteration across human cancers
Rameen Beroukhim,Craig H. Mermel,Craig H. Mermel,Dale Porter,Guo Wei,Soumya Raychaudhuri,Soumya Raychaudhuri,Jerry Donovan,Jordi Barretina,Jordi Barretina,Jesse S. Boehm,Jennifer Dobson,Jennifer Dobson,Mitsuyoshi Urashima,Kevin T. Mc Henry,Reid M. Pinchback,Azra H. Ligon,Yoon Jae Cho,Leila Haery,Leila Haery,Heidi Greulich,Michael R. Reich,Wendy Winckler,Michael S. Lawrence,Barbara A. Weir,Barbara A. Weir,Kumiko E. Tanaka,Kumiko E. Tanaka,Derek Y. Chiang,Derek Y. Chiang,Derek Y. Chiang,Adam J. Bass,Adam J. Bass,Adam J. Bass,Alice Loo,Carter Hoffman,Carter Hoffman,John R. Prensner,John R. Prensner,Ted Liefeld,Qing Gao,Derek Yecies,Sabina Signoretti,Sabina Signoretti,Elizabeth A. Maher,Frederic J. Kaye,Hidefumi Sasaki,Joel E. Tepper,Jonathan A. Fletcher,Josep Tabernero,José Baselga,Ming-Sound Tsao,Francesca Demichelis,Mark A. Rubin,Pasi A. Jänne,Pasi A. Jänne,Mark J. Daly,Mark J. Daly,Carmelo Nucera,Ross L. Levine,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert,Stacey Gabriel,Anil K. Rustgi,Cristina R. Antonescu,Marc Ladanyi,Anthony Letai,Levi A. Garraway,Levi A. Garraway,Massimo Loda,Massimo Loda,David G. Beer,Lawrence D. True,Aikou Okamoto,Scott L. Pomeroy,Samuel Singer,Todd R. Golub,Todd R. Golub,Todd R. Golub,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,William R. Sellers,Matthew Meyerson,Matthew Meyerson +86 more
TL;DR: It is demonstrated that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival, and a large majority of SCNAs identified in individual cancer types are present in several cancer types.
Journal ArticleDOI
Molecular Subgroups of Medulloblastoma: The Current Consensus
Michael D. Taylor,Paul A. Northcott,Andrey Korshunov,Marc Remke,Marc Remke,Yoon Jae Cho,Steven C. Clifford,Charles G. Eberhart,D. Williams Parsons,Stefan Rutkowski,Amar Gajjar,David W. Ellison,Peter Lichter,Richard J. Gilbertson,Scott L. Pomeroy,Marcel Kool,Stefan M. Pfister,Stefan M. Pfister +17 more
TL;DR: It is anticipated that the molecular classification of medulloblastoma will continue to evolve and diversify in the future as larger cohorts are studied at greater depth, and herein is outlined the current consensus nomenclature, and the differences between the medullOBlastoma subgroups.
Journal ArticleDOI
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
Leonora Balaj,Ryan T. Lessard,Lixin Dai,Yoon Jae Cho,Scott L. Pomeroy,Xandra O. Breakefield,Johan Skog +6 more
TL;DR: Tumour microvesicles contain a repertoire of genetic information available for horizontal gene transfer and potential use as blood biomarkers for cancer, including elevated levels of specific coding and non-coding RNA and DNA, mutated and amplified oncogene sequences and transposable elements.
Journal ArticleDOI
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
Marcel Kool,Andrey Korshunov,Marc Remke,Marc Remke,David T.W. Jones,Maria Schlanstein,Paul A. Northcott,Yoon Jae Cho,Jan Koster,Antoinette Y N Schouten-van Meeteren,Dannis G. van Vuurden,Steven C. Clifford,Torsten Pietsch,André O. von Bueren,Stefan Rutkowski,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Magnus Bäcklund,Christine Haberler,Franck Bourdeaut,Olivier Delattre,François Doz,David W. Ellison,Richard J. Gilbertson,Scott L. Pomeroy,Michael D. Taylor,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +29 more
TL;DR: A meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies shows how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival.
Journal ArticleDOI
Dissecting the genomic complexity underlying medulloblastoma
David T.W. Jones,Natalie Jäger,Marcel Kool,Thomas Zichner,Barbara Hutter,Marc Sultan,Yoon Jae Cho,Trevor J. Pugh,Volker Hovestadt,Adrian M. Stütz,Tobias Rausch,Hans-Jörg Warnatz,Marina Ryzhova,Sebastian Bender,Dominik Sturm,Sabrina Pleier,Huriye Cin,Elke Pfaff,Laura Sieber,Andrea Wittmann,Marc Remke,Hendrik Witt,Hendrik Witt,Sonja Hutter,Theophilos Tzaridis,Joachim Weischenfeldt,Benjamin Raeder,Meryem Avci,Vyacheslav Amstislavskiy,Marc Zapatka,Ursula D. Weber,Qi Wang,Bärbel Lasitschka,Cynthia C. Bartholomae,Manfred Schmidt,Christof von Kalle,Volker Ast,Chris Lawerenz,Jürgen Eils,Rolf Kabbe,Vladimir Benes,Peter van Sluis,Jan Koster,Richard Volckmann,David Shih,Matthew J. Betts,Robert B. Russell,Simona Coco,Gian Paolo Tonini,Ulrich Schüller,Volkmar Hans,Norbert Graf,Yoo-Jin Kim,Camelia M. Monoranu,Wolfgang Roggendorf,Andreas Unterberg,Christel Herold-Mende,Till Milde,Till Milde,Andreas E. Kulozik,Andreas von Deimling,Andreas von Deimling,Olaf Witt,Olaf Witt,Eberhard Maass,Jochen Rössler,Martin Ebinger,Martin U. Schuhmann,Michael C. Frühwald,Martin Hasselblatt,Nada Jabado,Stefan Rutkowski,André O. von Bueren,Daniel Williamson,Steven C. Clifford,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Stephan Wolf,Stefan Wiemann,Hans Lehrach,Benedikt Brors,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Paul A. Northcott,Michael D. Taylor,Matthew Meyerson,Matthew Meyerson,Scott L. Pomeroy,Scott L. Pomeroy,Marie-Laure Yaspo,Jan O. Korbel,Andrey Korshunov,Andrey Korshunov,Roland Eils,Roland Eils,Stefan M. Pfister,Stefan M. Pfister,Peter Lichter +99 more
TL;DR: An integrative deep-sequencing analysis of 125 tumour–normal pairs enhances the understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provides several potential targets for new therapeutics, especially for Group 3 and 4 patients.