M
Maina Lepourcelet
Researcher at Harvard University
Publications - 5
Citations - 1022
Maina Lepourcelet is an academic researcher from Harvard University. The author has contributed to research in topics: Wnt signaling pathway & TCF/LEF family. The author has an hindex of 5, co-authored 5 publications receiving 974 citations. Previous affiliations of Maina Lepourcelet include Brigham and Women's Hospital.
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Journal ArticleDOI
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
Maina Lepourcelet,Ying-Nan P. Chen,Huisheng Wang,Phillip Crews,Frank Petersen,Charles W. Bruseo,Alexander W. Wood,Ramesh A. Shivdasani,Ramesh A. Shivdasani +8 more
TL;DR: These compounds meet predicted criteria for disrupting Tcf/beta-catenin complexes and define a general standard to establish mechanism-based activity of small molecule inhibitors of this pathogenic protein-protein interaction.
Journal ArticleDOI
Structure of a human Tcf4-beta-catenin complex.
TL;DR: The crystal structure of a human Tcf4–β- catenin complex is described and it is compared with recent structures of β-catenin in complex with Xenopus Tcf3 (XTcf3) and mammalian E-cadherin to reveal anticipated similarities with the closely related XTcf3 complex but unexpectedly lacks one component observed in the XTcf2 structure.
Journal ArticleDOI
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development
Michael Y. Choi,Anthony I. Romer,Michael Hu,Maina Lepourcelet,Ambili Mechoor,Ayce Yesilaltay,Monty Krieger,Paul A. Gray,Ramesh A. Shivdasani,Ramesh A. Shivdasani +9 more
TL;DR: In this paper, the authors evaluated the dynamic expression during mouse gut organogenesis of 1381 transcripts, covering nearly every known and predicted tissue-restricted transcription factors (TFs), and documented the expression of approximately 1000 TF genes in gastrointestinal development.
Journal ArticleDOI
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF).
Maina Lepourcelet,Liqiang Tou,Li Cai,Jun-ichi Sawada,Alexander J. Lazar,Jonathan N. Glickman,Jessica A. Williamson,Allen D. Everett,Mark Redston,Edward A. Fox,Yoshihiro Nakatani,Ramesh A. Shivdasani +11 more
TL;DR: Serial analysis of gene expression to measure transcript levels across stages in mouse intestine development identifies novel differentiation products, potential effectors of epithelial-mesenchymal interactions, and candidate markers and regulators of intestinal epithelium and advances understanding of HDGF functions.
Journal ArticleDOI
Characterization of a Novel Mammalian Groucho Isoform and Its Role in Transcriptional Regulation
TL;DR: Findings suggest that Grg1-S may operate in conjunction with β-catenin and Tcf factors to regulate vertebrate gut epithelial cell differentiation.