M
Majella E. Lane
Researcher at University College London
Publications - 141
Citations - 5484
Majella E. Lane is an academic researcher from University College London. The author has contributed to research in topics: Stratum corneum & Transdermal. The author has an hindex of 32, co-authored 124 publications receiving 4701 citations. Previous affiliations of Majella E. Lane include University of London.
Papers
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Journal ArticleDOI
Skin penetration enhancers.
TL;DR: It is proposed that overall the effects of CPEs on the skin barrier may best be explained by a Diffusion-Partition-Solubility theory.
Journal ArticleDOI
Epidermal Barrier Dysfunction in Atopic Dermatitis
Michael J. Cork,Simon G. Danby,Yiannis Vasilopoulos,Jonathan Hadgraft,Majella E. Lane,Manar Moustafa,Manar Moustafa,Richard H. Guy,Alice Macgowan,Rachid Tazi-Ahnini,Simon J. Ward +10 more
TL;DR: The strong association between both genetic barrier defects and environmental insults to the barrier with AD suggests that epidermal barrier dysfunction is a primary event in the development of this disease.
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The structure and function of the stratum corneum
TL;DR: This review summarizes the major advances in understanding of the stratum corneum, the skin's outermost layer and interface with the outside world, and the molecular and genetic factors that determine the development of a competent permeability barrier.
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Mathematical models of skin permeability: An overview
Samir Mitragotri,Yuri German Anissimov,Annette L. Bunge,H. Frederick Frasch,Richard H. Guy,Jonathan Hadgraft,Gerald B. Kasting,Majella E. Lane,Michael S. Roberts +8 more
TL;DR: An overview of various modeling approaches of skin permeability with respect to their advantages, limitations and future prospects is provided.
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The relationship between transepidermal water loss and skin permeability
TL;DR: The results confirm the previous hypothesis and suggest that TEWL may be used to characterise the permeation routes for different anatomic sites, with generalisations that skin sites with smaller corneocytes have fewer cell layers, with shorter permeation pathlengths and higher TewL values.