S
Simon J. Ward
Researcher at University of Sheffield
Publications - 45
Citations - 2364
Simon J. Ward is an academic researcher from University of Sheffield. The author has contributed to research in topics: Atopic dermatitis & Retinoic acid. The author has an hindex of 17, co-authored 44 publications receiving 2259 citations. Previous affiliations of Simon J. Ward include Royal Hallamshire Hospital & French Institute of Health and Medical Research.
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Journal ArticleDOI
Epidermal Barrier Dysfunction in Atopic Dermatitis
Michael J. Cork,Simon G. Danby,Yiannis Vasilopoulos,Jonathan Hadgraft,Majella E. Lane,Manar Moustafa,Manar Moustafa,Richard H. Guy,Alice Macgowan,Rachid Tazi-Ahnini,Simon J. Ward +10 more
TL;DR: The strong association between both genetic barrier defects and environmental insults to the barrier with AD suggests that epidermal barrier dysfunction is a primary event in the development of this disease.
Journal ArticleDOI
New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene–environment interactions
Michael J. Cork,Michael J. Cork,Darren Robinson,Yiannis Vasilopoulos,Adam Ferguson,Manar Moustafa,Alice Macgowan,Gordon W. Duff,Simon J. Ward,Rachid Tazi-Ahnini +9 more
TL;DR: A new perspective is proposed on the importance of epidermal barrier dysfunction in genetically predisposed individuals, predisposing them to the harmful effects of environmental agents.
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5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells
TL;DR: This report indicates for the first time that 5-HT2B receptors are actively mediating the action of serotonin on embryonic morphogenesis, probably by preventing the differentiation of cranial neural crest cells and myocardial precursor cells.
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Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
Yiannis Vasilopoulos,Michael J. Cork,Ruth Murphy,Helen Williams,D.A. Robinson,G. W. Duff,Simon J. Ward,Rachid Tazi-Ahnini +7 more
TL;DR: The findings suggest that SCCE could have an important role in the development of atopic dermatitis, and a significant trend between the AACC allele with the two insertions and disease in the overall data set is found.
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Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis.
TL;DR: Addition of RA to the culture medium at the time of antisense injection restored normal development implicating the role of RBP in embryonic RA synthesis, and resulted in early down-regulation of developmentally important genes including TGF-beta1 and Shh.