M
Mamoru Arakawa
Researcher at Jichi Medical University
Publications - 47
Citations - 441
Mamoru Arakawa is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Aortic dissection & Ventricular assist device. The author has an hindex of 11, co-authored 46 publications receiving 353 citations. Previous affiliations of Mamoru Arakawa include Stanford University.
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Journal ArticleDOI
In-body tissue-engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding.
Yasuhide Nakayama,Yoshiaki Takewa,Hirohito Sumikura,Masashi Yamanami,Yuichi Matsui,Tomonori Oie,Yuichiro Kishimoto,Mamoru Arakawa,Kentaro Ohmuma,Tsutomu Tajikawa,Keiichi Kanda,Eisuke Tatsumi +11 more
TL;DR: Functional, autologous, 3D-shaped heart valves with clinical application potential were formed following in-body embedding of specially designed molds that were created within several hours by 3D printer.
Journal ArticleDOI
Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat.
Yuichiro Kishimoto,Yoshiaki Takewa,Mamoru Arakawa,Akihide Umeki,Masahiko Ando,Takashi Nishimura,Yutaka Fujii,Toshihide Mizuno,Motonobu Nishimura,Eisuke Tatsumi +9 more
TL;DR: This novel drive mode may considerably benefit patients with severe heart failure on long-term LVAD support by preventing AI by providing both minimal support for early systole and maximal support shortly after aortic valve opening by changing the RS in synchronization with heartbeat.
Journal ArticleDOI
Dual Modality Activity Based Probes as Molecular Imaging Agents for Vascular Inflammation
Nimali P. Withana,Toshinobu Saito,Xiaowei Ma,Megan Garland,Changhao Liu,Hisanori Kosuge,Myriam Amsallem,Martijn Verdoes,Leslie O. Ofori,Michael P. Fischbein,Mamoru Arakawa,Zhen Cheng,Michael V. McConnell,Matthew Bogyo +13 more
TL;DR: Activity-based probes targeting cysteine cathepsins can be used in murine models of atherosclerosis to noninvasively image activated macrophage populations using both optical and PET/CT methods and demonstrate substantial infiltration of macrophages in the neointima and adventitia of the ligated left carotid arteries compared with the right.
Journal ArticleDOI
Gene expression profiling of acute type A aortic dissection combined with in vitro assessment
Naoyuki Kimura,Kyoko Futamura,Mamoru Arakawa,Naoko Okada,Fabian Emrich,Homare Okamura,Tetsuya Sato,Yasuhiro Shudo,Tiffany K Koyano,Atsushi Yamaguchi,Hideo Adachi,Akio Matsuda,Koji Kawahito,Kenji Matsumoto,Michael P. Fischbein +14 more
TL;DR: Results of the novel approach, integrating in vitro assessment into gene expression profiling, implicated chronic inflammation characterized by MMP‐TIMP dysregulation, increased VEGFA expression, and TGF‐&bgr; signalling in the development of dissection.
Journal ArticleDOI
Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras-Induced ERK (Extracellular Signal-Regulated Kinase) Signaling Pathway.
Tetsuya Sato,Mamoru Arakawa,Mamoru Arakawa,Yasushi Tashima,Yasushi Tashima,Eitoshi Tsuboi,Grayson Burdon,Jeffrey Trojan,Tiffany K Koyano,Young-Nam Youn,Young-Nam Youn,Kiril Penov,Kiril Penov,Albert J. Pedroza,Mohammad Shabazzi,Itai Palmon,Marie Noel Nguyen,Andrew J. Connolly,Atsushi Yamaguchi,Michael P. Fischbein +19 more
TL;DR: Aneurysm reduction in Fbn1 C1039G/+ mice following pravastatin and MA treatment was associated with a decrease in Ras‐dependent ERK signaling and MMP activity, which can be reduced by diminishing Ras signaling.