M
Manel Ouji
Researcher at University of Toulouse
Publications - 6
Citations - 143
Manel Ouji is an academic researcher from University of Toulouse. The author has contributed to research in topics: Artemisinin & Plasmodium falciparum. The author has an hindex of 4, co-authored 6 publications receiving 80 citations. Previous affiliations of Manel Ouji include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination.
TL;DR: It is essential to understand the acquisition of resistance to artemisinins by Plasmodium falciparum to adapt malaria treatment policies and to propose new therapeutic solutions.
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Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism.
Lucie Paloque,Lucie Paloque,Benoit Witkowski,Benoit Witkowski,Benoit Witkowski,Joël Lelièvre,Joël Lelièvre,Manel Ouji,Manel Ouji,Tanila Ben Haddou,Tanila Ben Haddou,Frédéric Ariey,Anne Robert,Anne Robert,Jean-Michel Augereau,Jean-Michel Augereau,Didier Menard,Bernard Meunier,Bernard Meunier,Françoise Benoit-Vical,Françoise Benoit-Vical +20 more
TL;DR: Worrisome results indicate the risk of cross-resistance between artemisinins and endoperoxide-based antiplasmodial drugs in the development of the K13 mutant parasites and question the usefulness of these molecules in the future therapeutic arsenal.
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Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites
Manel Ouji,Guillaume Barnoin,Álvaro Fernández Álvarez,Jean-Michel Augereau,Catherine Hemmert,Françoise Benoit-Vical,Heinz Gornitzka +6 more
TL;DR: Concerns are raised about the use of hybrid molecules combining a dihydroartemisinin derivative and gold(I) N-heterocyclic carbene (NHC) complexes based on the different modes of action of the two compounds in future therapeutic malaria policies.
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Identification of compounds active against quiescent artemisinin-resistant Plasmodium falciparum parasites via the quiescent-stage survival assay (QSA).
Thibaud Reyser,Lucie Paloque,Manel Ouji,Michel Nguyen,Sandie Menard,Benoit Witkowski,Jean-Michel Augereau,Françoise Benoit-Vical,Françoise Benoit-Vical +8 more
TL;DR: These data confirm the high relevance of adding the chemosensitivity evaluation of quiescent parasites by the specific in vitro QSA to the antiplasmodial drug development process in the current worrisome context of artemisinin resistance.
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Design, Synthesis and Efficacy of Hybrid Triclosan‐gold Based Molecules on Artemisinin‐resistant Plasmodium falciparum and Leishmania infantum Parasites
Manel Ouji,Sandra Bourgeade Delmas,Álvaro Fernández Álvarez,Jean-Michel Augereau,Alexis Valentin,Catherine Hemmert,Heinz Gornitzka,Françoise Benoit-Vical,Françoise Benoit-Vical +8 more
TL;DR: In this paper, several hybrid molecules combining triclosan and gold(I) complexes have been synthesized and evaluated, in vitro, for their activities on P. falciparum and L. infantum parasites.