L
Lucie Paloque
Researcher at University of Toulouse
Publications - 24
Citations - 486
Lucie Paloque is an academic researcher from University of Toulouse. The author has contributed to research in topics: Plasmodium falciparum & Artemisinin. The author has an hindex of 9, co-authored 23 publications receiving 356 citations. Previous affiliations of Lucie Paloque include French Institute of Health and Medical Research & University of the Mediterranean.
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Journal ArticleDOI
Plasmodium falciparum: multifaceted resistance to artemisinins.
Lucie Paloque,Lucie Paloque,Arba Pramundita Ramadani,Arba Pramundita Ramadani,Arba Pramundita Ramadani,Odile Mercereau-Puijalon,Jean-Michel Augereau,Jean-Michel Augereau,Françoise Benoit-Vical,Françoise Benoit-Vical +9 more
TL;DR: The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s).
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Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination.
TL;DR: It is essential to understand the acquisition of resistance to artemisinins by Plasmodium falciparum to adapt malaria treatment policies and to propose new therapeutic solutions.
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Synthesis, Structures, and Biological Studies of Heterobimetallic Au(I)–Ru(II) Complexes Involving N-Heterocyclic Carbene-Based Multidentate Ligands
Luca Boselli,Maëlle Carraz,Serge Mazères,Lucie Paloque,German Gonzalez,Françoise Benoit-Vical,Alexis Valentin,Catherine Hemmert,Heinz Gornitzka +8 more
TL;DR: In this article, three heterobimetallic gold(I)-ruthenium(II) complexes containing heteroditopic bipyridine-N-heterocyclic carbene (NHC) ligands were synthesized and fully characterized by spectroscopic methods and in one case by single-crystal X-ray diffraction.
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Targeting the human parasite Leishmania donovani: discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series.
Caroline Castera-Ducros,Lucie Paloque,Pierre Verhaeghe,Magali Casanova,Christophe Cantelli,Sébastien Hutter,Floriane Tanguy,Michèle Laget,Vincent Remusat,Anita Cohen,Maxime D. Crozet,Pascal Rathelot,Nadine Azas,Patrice Vanelle +13 more
TL;DR: The 6-halo-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridine scaffold appears as a new promising selective antileishmanial pharmacophore, especially when substituted at position 8 by a bromine atom.
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Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study.
Julien Pedron,Clotilde Boudot,Sébastien Hutter,Sandra Bourgeade-Delmas,Jean-Luc Stigliani,Alix Sournia-Saquet,Alain Moreau,Elisa Boutet-Robinet,Lucie Paloque,Emmanuelle Mothes,Michèle Laget,Laure Vendier,Geneviève Pratviel,Susan Wyllie,Alan H. Fairlamb,Nadine Azas,Bertrand Courtioux,Alexis Valentin,Pierre Verhaeghe +18 more
TL;DR: Compound 22 is a new hit compound, displaying both antileishmanial and antitrypanosomal activity along with a low cytotoxicity on the human HepG2 cell line, and despite being mutagenic in the Ames test, compound 22 was not genotoxic in the comet assay.